Dydrogesterone affects the transcription of genes in GnRH and steroidogenesis pathways and increases the frequency of atretic follicles in zebrafish (Danio rerio).

Animals Dydrogesterone / metabolism Female Gonadotropin-Releasing Hormone / metabolism Male Ovarian Follicle / drug effects Zebrafish
Dydrogesterone GnRH signaling pathway Histopathology Steroidogenesis Transcription

Journal

Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 21 08 2018
revised: 28 10 2018
accepted: 29 10 2018
pubmed: 6 11 2018
medline: 2 2 2019
entrez: 5 11 2018
Statut: ppublish

Résumé

Dydrogesterone (DDG) is a synthetic progestin broadly used in human and veterinary medicine and has been widely detected in aquatic environments. However, its potential effects on aquatic organisms are little documented. Here we investigate the short-term effects of DDG on the transcriptional and histological responses in adult zebrafish (Danio rerio). Adult zebrafish were exposed to 32.0, 305 and 2490 ng L

Identifiants

DOI: 10.1016/j.chemosphere.2018.10.202 PMID: 30391894
pubmed: 30391894
pii: S0045-6535(18)32077-0
doi: 10.1016/j.chemosphere.2018.10.202
pii:
doi:

Substances chimiques

Gonadotropin-Releasing Hormone 33515-09-2
Dydrogesterone 90I02KLE8K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

725-732

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Wen-Jun Shi (WJ)

The Environmental Research Institute, MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China; State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Li-Xin Hu (LX)

The Environmental Research Institute, MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China.

Guo-Yong Huang (GY)

The Environmental Research Institute, MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China.

You-Sheng Liu (YS)

The Environmental Research Institute, MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China.

Jin-Na Zhang (JN)

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Lingtian Xie (L)

The Environmental Research Institute, MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China.

Guang-Guo Ying (GG)

The Environmental Research Institute, MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China. Electronic address: guangguo.ying@m.scnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dydrogesterone affects the transcription of...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnadiènes › Dydrogestérone › Dydrogesterone affects the transcription of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Hormone de libération des gonadotrophines › Dydrogesterone affects the transcription of...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Gonades › Ovaire › Follicule ovarique › Dydrogesterone affects the transcription of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Dydrogesterone affects the transcription of...