Antimicrobial proteins: intestinal guards to protect against liver disease.
Bacterial Proteins
/ physiology
Bacterial Translocation
/ physiology
Defensins
/ physiology
Dysbiosis
/ microbiology
Fatty Liver, Alcoholic
/ microbiology
Gastrointestinal Microbiome
/ physiology
Humans
Immunity, Innate
/ physiology
Intestines
/ microbiology
Lectins, C-Type
/ physiology
Liver Cirrhosis
/ microbiology
Liver Diseases
/ microbiology
Non-alcoholic Fatty Liver Disease
/ microbiology
Symbiosis
/ physiology
Bacterial translocation
Dysbiosis
Innate immune system
Microbiome
Journal
Journal of gastroenterology
ISSN: 1435-5922
Titre abrégé: J Gastroenterol
Pays: Japan
ID NLM: 9430794
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
02
10
2018
accepted:
19
10
2018
pubmed:
6
11
2018
medline:
19
6
2020
entrez:
5
11
2018
Statut:
ppublish
Résumé
Alterations of gut microbes play a role in the pathogenesis and progression of many disorders including liver and gastrointestinal diseases. Both qualitative and quantitative changes in gut microbiota have been associated with liver disease. Intestinal dysbiosis can disrupt the integrity of the intestinal barrier leading to pathological bacterial translocation and the initiation of an inflammatory response in the liver. In order to sustain symbiosis and protect from pathological bacterial translocation, antimicrobial proteins (AMPs) such as a-defensins and C-type lectins are expressed in the gastrointestinal tract. In this review, we provide an overview of the role of AMPs in different chronic liver disease such as alcoholic steatohepatitis, non-alcoholic fatty liver disease, and cirrhosis. In addition, potential approaches to modulate the function of AMPs and prevent bacterial translocation are discussed.
Identifiants
pubmed: 30392013
doi: 10.1007/s00535-018-1521-8
pii: 10.1007/s00535-018-1521-8
pmc: PMC6391196
mid: NIHMS1511511
doi:
Substances chimiques
Bacterial Proteins
0
Defensins
0
Lectins, C-Type
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
209-217Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA020703
Pays : United States
Organisme : BLRD VA
ID : I01 BX004594
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024726
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021856
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA024726
Pays : United States
Organisme : BLRD VA
ID : I01 BX002213
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA026939
Pays : United States
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