RA-XXV and RA-XXVI, Bicyclic Hexapeptides from Rubia cordifolia L.: Structure, Synthesis, and Conformation.
Rubia cordifolia
conformation
peptides
structure elucidation
synthesis
Journal
Chemistry, an Asian journal
ISSN: 1861-471X
Titre abrégé: Chem Asian J
Pays: Germany
ID NLM: 101294643
Informations de publication
Date de publication:
04 Jan 2019
04 Jan 2019
Historique:
received:
04
10
2018
revised:
29
10
2018
pubmed:
6
11
2018
medline:
5
2
2019
entrez:
6
11
2018
Statut:
ppublish
Résumé
Two RA-series bicyclic hexapeptides, RA-XXV (4) and RA-XXVI (5), which have no N-methyl group at Tyr-5, were isolated from the roots of Rubia cordifolia L. Their amino acid compositions and sequences were determined by interpretation of MS, and 1D and 2D NMR data and their relative structures were elucidated by XRD analysis of 4 and RA-XXVI acetate (6). The absolute stereochemistry of 4 was established by the total synthesis of 4, and that of 5, by the chemical correlation with 4. Peptides 4 and 5 exhibited cytotoxicity toward human promyelocytic leukemia HL-60 (IC
Identifiants
pubmed: 30393964
doi: 10.1002/asia.201801466
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Peptides, Cyclic
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-215Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.