Biomimetic sponges for regeneration of skeletal muscle following trauma.
extracellular matrix
myogenesis
volumetric muscle loss
Journal
Journal of biomedical materials research. Part A
ISSN: 1552-4965
Titre abrégé: J Biomed Mater Res A
Pays: United States
ID NLM: 101234237
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
18
05
2018
revised:
17
08
2018
accepted:
21
08
2018
pubmed:
6
11
2018
medline:
1
4
2020
entrez:
6
11
2018
Statut:
ppublish
Résumé
Skeletal muscle is inept in regenerating after traumatic injuries due to significant loss of basal lamina and the resident satellite cells. To improve regeneration of skeletal muscle, we have developed biomimetic sponges composed of collagen, gelatin, and laminin (LM)-111 that were crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC). Collagen and LM-111 are crucial components of the muscle extracellular matrix and were chosen to impart bioactivity whereas gelatin and EDC were used to provide mechanical strength to the scaffold. Morphological and mechanical evaluation of the sponges showed porous structure, water-retention capacity and a compressive modulus of 590-808 kPa. The biomimetic sponges supported the infiltration and viability of C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
92-103Informations de copyright
© 2018 Wiley Periodicals, Inc.