Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders.
canine
chemotherapy
entotherapy
glioma
magnetic resonance imaging
Journal
Veterinary medicine and science
ISSN: 2053-1095
Titre abrégé: Vet Med Sci
Pays: England
ID NLM: 101678837
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
6
11
2018
medline:
10
4
2019
entrez:
6
11
2018
Statut:
ppublish
Résumé
Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client-owned dogs with gliomas. All four dogs presented with generalized seizures and had mild to no neurologic deficits at the time of craniotomy. All dogs underwent craniotomy for implantation of the microcylinders into partially resected gliomas (glioblastoma multiforme {n = 1} or oligodendroglioma {n = 3}). All dogs recovered well from the craniotomy and implantation procedure. This novel procedure appears to be feasible and tolerated in tumour-bearing dogs. A future controlled clinical study can now aim to evaluate the microcylinder implantation for long-term efficacy.
Identifiants
pubmed: 30394686
doi: 10.1002/vms3.124
pmc: PMC6376143
doi:
Substances chimiques
Antineoplastic Agents, Alkylating
0
Drug Implants
0
Temozolomide
YF1K15M17Y
Types de publication
Clinical Trial, Veterinary
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5-18Informations de copyright
© 2018 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd.
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