Acute administration of tirofiban versus aspirin in emergent carotid artery stenting.
Aged
Aspirin
/ administration & dosage
Carotid Stenosis
/ surgery
Cerebral Angiography
Female
Fibrinolytic Agents
/ administration & dosage
Humans
Male
Middle Aged
Retrospective Studies
Stents
Stroke
/ prevention & control
Tirofiban
/ administration & dosage
Tomography, X-Ray Computed
Treatment Outcome
Tirofiban
emergent carotid artery stenting
stroke
Journal
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
ISSN: 2385-2011
Titre abrégé: Interv Neuroradiol
Pays: United States
ID NLM: 9602695
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
pubmed:
6
11
2018
medline:
6
8
2019
entrez:
6
11
2018
Statut:
ppublish
Résumé
Carotid artery stenting requires antiplatelet therapy for prevention of in-stent thrombosis. Patients suffering from acute ischemic stroke undergoing intravenous thrombolysis and emergent carotid artery stenting (eCAS) are at high risk for intracranial bleeding. We assessed efficacy and safety of acute administration of intravenous tirofiban versus aspirin in these patients. A retrospective, single center, cohort study was carried out of 32 patients who underwent eCAS (18 received tirofiban, 14 received aspirin) at our comprehensive stroke center (2008-2016). Of our 32 consecutive eCAS patients, favorable clinical outcomes (modified Rankin scale ≤ 2) were achieved in eight (47%) tirofiban patients and six (46%) aspirin patients ( p = 0.96). Overall rates were similar for symptomatic intracranial bleeding (tirofiban 22%, aspirin 29%, p = 0.68) and mortality (tirofiban 18%, aspirin 23%, p = 0.71). Tirofiban and aspirin demonstrated similar efficacy and safety in thrombolyzed stroke patients who underwent eCAS in our cohort. Intravenous tirofiban with its short half-life might represent an alternative to aspirin in select patients.
Sections du résumé
BACKGROUND
BACKGROUND
Carotid artery stenting requires antiplatelet therapy for prevention of in-stent thrombosis. Patients suffering from acute ischemic stroke undergoing intravenous thrombolysis and emergent carotid artery stenting (eCAS) are at high risk for intracranial bleeding. We assessed efficacy and safety of acute administration of intravenous tirofiban versus aspirin in these patients.
METHODS
METHODS
A retrospective, single center, cohort study was carried out of 32 patients who underwent eCAS (18 received tirofiban, 14 received aspirin) at our comprehensive stroke center (2008-2016).
RESULTS
RESULTS
Of our 32 consecutive eCAS patients, favorable clinical outcomes (modified Rankin scale ≤ 2) were achieved in eight (47%) tirofiban patients and six (46%) aspirin patients ( p = 0.96). Overall rates were similar for symptomatic intracranial bleeding (tirofiban 22%, aspirin 29%, p = 0.68) and mortality (tirofiban 18%, aspirin 23%, p = 0.71).
CONCLUSIONS
CONCLUSIONS
Tirofiban and aspirin demonstrated similar efficacy and safety in thrombolyzed stroke patients who underwent eCAS in our cohort. Intravenous tirofiban with its short half-life might represent an alternative to aspirin in select patients.
Identifiants
pubmed: 30394839
doi: 10.1177/1591019918808777
pmc: PMC6448368
doi:
Substances chimiques
Fibrinolytic Agents
0
Tirofiban
GGX234SI5H
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Langues
eng
Pagination
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