Prevalence and Correlates of β- and γ-Human Papillomavirus Detection in Oral Samples From Mid-Adult Women.
mid-adult
oral cavity
women
β-HPV
γ-HPV
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
15 03 2019
15 03 2019
Historique:
received:
21
07
2018
accepted:
29
10
2018
pubmed:
6
11
2018
medline:
14
1
2020
entrez:
6
11
2018
Statut:
ppublish
Résumé
Little is known about the epidemiology of β and γ human papillomaviruses (HPVs) in oral cavities of healthy women. We performed multiplex polymerase chain reaction analysis for detection of 46 β-HPVs and 51 γ-HPVs in stored oral rinse samples from healthy mid-adult women (age, 30-50 years). A total of 407 women were tested for β-HPVs, and 310 were tested for γ-HPVs. We used log-binomial regression to identify determinants of β-HPV and γ-HPV in separate models. Using paired fingernail data from a subset of 184 women, we also evaluated whether fingernail β-HPV detection was associated with concurrent detection of the same type in the oral cavity. Oral HPV prevalence was 20.6% for β-HPV and 10.7% for γ-HPV. In multivariate analysis, oral β-HPV detection was associated with increasing age (adjusted prevalence ratio [aPR] per 5-year difference, 1.37; 95% confidence interval [CI], 1.01-1.86) and a greater lifetime number of oral sex partners (aPR for reporting ≥6 vs 0-5 partners, 2.06; 95% CI, 1.01-4.20). In a separate model, concurrent detection of the same β-HPV type in fingernails was strongly associated with oral β-HPV detection (aPR, 31.44; 95% CI, 19.81-49.49). No significant determinants of γ-HPV detection were identified. Our results suggest a sexual transmission route for β-HPVs and support the hypothesis that fingers may serve as a source of transmission or autoinoculation of β-HPVs to the oral cavity.
Sections du résumé
BACKGROUND
Little is known about the epidemiology of β and γ human papillomaviruses (HPVs) in oral cavities of healthy women.
METHODS
We performed multiplex polymerase chain reaction analysis for detection of 46 β-HPVs and 51 γ-HPVs in stored oral rinse samples from healthy mid-adult women (age, 30-50 years). A total of 407 women were tested for β-HPVs, and 310 were tested for γ-HPVs. We used log-binomial regression to identify determinants of β-HPV and γ-HPV in separate models. Using paired fingernail data from a subset of 184 women, we also evaluated whether fingernail β-HPV detection was associated with concurrent detection of the same type in the oral cavity.
RESULTS
Oral HPV prevalence was 20.6% for β-HPV and 10.7% for γ-HPV. In multivariate analysis, oral β-HPV detection was associated with increasing age (adjusted prevalence ratio [aPR] per 5-year difference, 1.37; 95% confidence interval [CI], 1.01-1.86) and a greater lifetime number of oral sex partners (aPR for reporting ≥6 vs 0-5 partners, 2.06; 95% CI, 1.01-4.20). In a separate model, concurrent detection of the same β-HPV type in fingernails was strongly associated with oral β-HPV detection (aPR, 31.44; 95% CI, 19.81-49.49). No significant determinants of γ-HPV detection were identified.
CONCLUSIONS
Our results suggest a sexual transmission route for β-HPVs and support the hypothesis that fingers may serve as a source of transmission or autoinoculation of β-HPVs to the oral cavity.
Identifiants
pubmed: 30395247
pii: 5149824
doi: 10.1093/infdis/jiy632
pmc: PMC6420166
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1067-1075Subventions
Organisme : World Health Organization
ID : 001
Pays : International
Organisme : NIAID NIH HHS
ID : P30 AI027757
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI103322
Pays : United States
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Références
J Infect. 2015 Jul;71(1):74-84
pubmed: 25698067
J Infect Dis. 2013 Oct 15;208(8):1335-41
pubmed: 23878325
Sex Transm Dis. 2015 Dec;42(12):677-85
pubmed: 26562696
J Med Microbiol. 2012 Nov;61(Pt 11):1538-45
pubmed: 22899778
Open Forum Infect Dis. 2017 Jan 31;4(1):ofw216
pubmed: 28480229
PLoS Pathog. 2018 Jan 11;14(1):e1006783
pubmed: 29324843
Exp Dermatol. 2009 Oct;18(10):857-62
pubmed: 19469900
J Skin Cancer. 2016;2016:1368103
pubmed: 27891253
Int J Cancer. 2015 Nov 15;137(10):2432-42
pubmed: 25976733
J Clin Virol. 2013 Jan;56(1):72-6
pubmed: 23092620
J Clin Virol. 2013 Dec;58(4):652-9
pubmed: 24210970
Papillomavirus Res. 2018 Jun;5:1-5
pubmed: 29807613
Papillomavirus Res. 2017 Jun;3:66-72
pubmed: 28720458
Curr Opin Virol. 2017 Oct;26:56-62
pubmed: 28778034
JAMA Oncol. 2016 May 1;2(5):606-607
pubmed: 26797496
Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):719-27
pubmed: 23396961
JAMA Oncol. 2016 May 1;2(5):599-606
pubmed: 26794505
J Clin Microbiol. 2010 Jan;48(1):143-9
pubmed: 19864475
J Clin Microbiol. 2006 Feb;44(2):504-12
pubmed: 16455905
J Clin Microbiol. 2007 Aug;45(8):2537-44
pubmed: 17581938
Int J Cancer. 2014 May 1;134(9):2231-44
pubmed: 24136717
J Clin Virol. 2016 Sep;82:159-165
pubmed: 27500365
Science. 1988 Jan 29;239(4839):487-91
pubmed: 2448875
Cancer Epidemiol Biomarkers Prev. 2017 Aug;26(8):1312-1320
pubmed: 28377417
J Infect Dis. 2017 Jul 1;216(1):92-96
pubmed: 28549147
Vaccine. 2013 Dec 31;31 Suppl 7:H1-31
pubmed: 24332295
Sci Rep. 2018 May 29;8(1):8241
pubmed: 29844517
Int J Cancer. 2005 Mar 1;113(6):946-50
pubmed: 15514945
Virology. 2013 Oct;445(1-2):2-10
pubmed: 23683837
MMWR Morb Mortal Wkly Rep. 2016 Jul 08;65(26):661-6
pubmed: 27387669
J Infect Dis. 2013 Nov 15;208(10):1643-52
pubmed: 24014882
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Apr;115(4):505-14
pubmed: 23375488
PLoS One. 2014 Sep 08;9(9):e104843
pubmed: 25198694
Am J Transplant. 2011 Jul;11(7):1498-508
pubmed: 21718442
Virology. 2016 Aug;495:33-41
pubmed: 27161202
PLoS Pathog. 2012;8(7):e1002807
pubmed: 22807682
J Infect Dis. 2011 Sep 1;204(5):787-92
pubmed: 21844305
PLoS Pathog. 2011 Jul;7(7):e1002125
pubmed: 21779166
J Clin Virol. 2015 Jun;67:47-51
pubmed: 25959158
J Gen Virol. 2013 Nov;94(Pt 11):2480-2488
pubmed: 23997181
J Infect Dis. 2018 Jul 2;218(3):388-397
pubmed: 29982800