Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.
Bile Duct Neoplasms
/ surgery
Cholestasis
/ complications
Down-Regulation
/ genetics
Drainage
/ methods
Female
Gene Expression
/ genetics
Hepatitis
/ genetics
Humans
Klatskin Tumor
/ surgery
Liver Cirrhosis
/ genetics
Male
Microarray Analysis
Middle Aged
Preoperative Care
/ methods
Signal Transduction
/ genetics
Up-Regulation
/ genetics
Journal
The British journal of surgery
ISSN: 1365-2168
Titre abrégé: Br J Surg
Pays: England
ID NLM: 0372553
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
11
05
2018
revised:
12
09
2018
accepted:
18
09
2018
pubmed:
6
11
2018
medline:
30
4
2019
entrez:
6
11
2018
Statut:
ppublish
Résumé
Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures.
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-58Informations de copyright
© 2018 BJS Society Ltd Published by John Wiley & Sons Ltd.