In vitro activity of cefiderocol, a siderophore cephalosporin, against a recent collection of clinically relevant carbapenem-non-susceptible Gram-negative bacilli, including serine carbapenemase- and metallo-β-lactamase-producing isolates (SIDERO-WT-2014 Study).
Acinetobacter baumannii
/ drug effects
Anti-Bacterial Agents
/ pharmacology
Bacterial Proteins
/ metabolism
Carbapenem-Resistant Enterobacteriaceae
/ drug effects
Cephalosporins
/ pharmacology
Drug Resistance, Multiple, Bacterial
/ drug effects
Escherichia coli
/ drug effects
Klebsiella pneumoniae
/ drug effects
Microbial Sensitivity Tests
Pseudomonas aeruginosa
/ drug effects
beta-Lactamases
/ metabolism
Cefiderocol
Gram-negative bacteria
carbapenemase
cefiderocol
meropenem-non-susceptible
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
27
06
2018
revised:
12
10
2018
accepted:
20
10
2018
pubmed:
6
11
2018
medline:
17
5
2019
entrez:
6
11
2018
Statut:
ppublish
Résumé
Cefiderocol is a siderophore cephalosporin in development for treatment of infections caused by Gram-negative bacilli, including carbapenem-resistant and multidrug-resistant isolates. β-Lactamase carriage and in vitro activity of cefiderocol were determined against 1272 meropenem-non-susceptible isolates of Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii collected as part of the SIDERO-WT-2014 surveillance study. Minimum inhibitory concentration (MIC) values for cefiderocol were ≤4 µg/mL against 97.7% of tested isolates, including 100% of IMP-positive (range, 1-2 µg/mL), OXA-58-positive (MIC
Identifiants
pubmed: 30395986
pii: S0924-8579(18)30299-1
doi: 10.1016/j.ijantimicag.2018.10.007
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Cephalosporins
0
beta-Lactamases
EC 3.5.2.6
carbapenemase
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-184Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.