Bioactive scalemic caged xanthones from the leaves of Garcinia bracteata.
Caged xanthones
Cytotoxicity
Garcibractatin A
Garcinia bracteate
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
06
07
2018
revised:
18
10
2018
accepted:
22
10
2018
pubmed:
6
11
2018
medline:
31
8
2019
entrez:
6
11
2018
Statut:
ppublish
Résumé
Four pairs of previously undescribed caged xanthones (1-4) and twelve known caged xanthones (5-16) were isolated from the leaf extract of Garcinia bracteata. Their structures were unambiguously elucidated on the basis of spectroscopic methods. The planar structure and relative configuration of 1 was confirmed by X-ray crystallographic analysis. The enantiomers of compounds 1, 2, 4 were further resolved by semi-preparative chiral HPLC, and the absolute configurations of enantiomers of compounds 1 and 4 were determined by measurement and calculation of electronic circular dichroism (ECD) spectra and specific rotations. The inhibitory activities of the isolated compounds against human HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines were assayed, and garcibractatin A (4) showed the most potent inhibitory activities in vitro with IC
Identifiants
pubmed: 30396061
pii: S0045-2068(18)30668-0
doi: 10.1016/j.bioorg.2018.10.041
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Xanthones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
274-283Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.