Evaluation of angiotensin converting enzyme inhibitors by SPR biosensor and theoretical studies.

Angiotensin-Converting Enzyme Inhibitors / chemistry Biosensing Techniques / methods High-Throughput Screening Assays Models, Theoretical Onopordum / chemistry Plant Extracts / pharmacology Surface Plasmon Resonance / methods
Angiotensin converting enzyme Drug discovery Inhibitor Medicinal plants Surface plasmon resonance

Journal

Enzyme and microbial technology
ISSN: 1879-0909
Titre abrégé: Enzyme Microb Technol
Pays: United States
ID NLM: 8003761

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 19 09 2017
revised: 13 06 2018
accepted: 19 10 2018
entrez: 7 11 2018
pubmed: 7 11 2018
medline: 23 2 2019
Statut: ppublish

Résumé

Surface plasmon resonance (SPR) biosensor has been utilized for monitoring analyte-ligand interactions in modern drug discovery processes. SPR biosensors measure the change in refractive indexes over the course of analyte molecules' binding to a specific immobilized ligand on sensor chip. This effort highlights a comprehensive SPR study besides enzymatic assay for discovery of new Angiotensin Converting Enzyme (ACE) inhibitors via screening of medicinal plants. At first, five medicinal plants were selected as potential sources for developing new ACE inhibitors through hydrolyzing hippuryl-L-histidyl-L-leucine (HHL) assay. The interaction of selected extracts with immobilized ACE on the sensor chip (500D) confirmed that the Onopordum acanthium L. had the greatest ACE inhibition activity among the set of compounds and its active compound (onopordia) was isolated. SPR biosensor used to evaluate binding affinity of onopordia and ACE. Equilibrium constant (K

Identifiants

DOI: 10.1016/j.enzmictec.2018.10.010 PMID: 30396392
pubmed: 30396392
pii: S0141-0229(18)30187-X
doi: 10.1016/j.enzmictec.2018.10.010
pii:
doi:

Substances chimiques

Angiotensin-Converting Enzyme Inhibitors 0
Plant Extracts 0

Types de publication

Evaluation Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

117-123

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Hafezeh Salehabadi (H)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176-53955, Iran.

Khosro Khajeh (K)

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran.

Bahareh Dabirmanesh (B)

Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115-111, Iran.

Mahmood Biglar (M)

Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 14176-53955, Iran.

Massoud Amanlou (M)

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176-53955, Iran; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 14176-53955, Iran. Electronic address: amanlou@tums.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Inhibiteurs de l'enzyme de conversion de l'angiotensine › Evaluation of angiotensin converting enzyme...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Evaluation of angiotensin converting enzyme...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › Evaluation of angiotensin converting enzyme...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Evaluation of angiotensin converting enzyme...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Onopordum › Evaluation of angiotensin converting enzyme...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Evaluation of angiotensin converting enzyme...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Résonance plasmonique de surface › Evaluation of angiotensin converting enzyme...