DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.
Animals
Caenorhabditis elegans
/ genetics
Caenorhabditis elegans Proteins
/ genetics
Cytoskeletal Proteins
/ genetics
Gene Expression Regulation, Developmental
Larva
/ genetics
MAP Kinase Kinase Kinases
/ genetics
Mutation
Nerve Regeneration
/ genetics
Neuronal Outgrowth
/ genetics
Neuronal Plasticity
/ genetics
Neurons
/ metabolism
Nuclear Proteins
/ genetics
Protein Interaction Domains and Motifs
Signal Transduction
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
07 01 2019
07 01 2019
Historique:
received:
30
04
2018
revised:
09
09
2018
accepted:
24
10
2018
pubmed:
7
11
2018
medline:
23
10
2019
entrez:
7
11
2018
Statut:
ppublish
Résumé
Neuronal morphology and circuitry established during early development must often be maintained over the entirety of animal lifespans. Compared with neuronal development, the mechanisms that maintain mature neuronal structures and architecture are little understood. The conserved disco-interacting protein 2 (DIP2) consists of a DMAP1-binding domain and two adenylate-forming domains (AFDs). We show that the
Identifiants
pubmed: 30396999
pii: jcb.201804207
doi: 10.1083/jcb.201804207
pmc: PMC6314549
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Cytoskeletal Proteins
0
EFA-6 protein, C elegans
0
Nuclear Proteins
0
dip-2 protein, C elegans
0
DLK-1 protein, C elegans
EC 2.7.11.25
MAP Kinase Kinase Kinases
EC 2.7.11.25
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-133Subventions
Organisme : NINDS NIH HHS
ID : R01 NS093588
Pays : United States
Organisme : CIHR
ID : 123513
Pays : Canada
Informations de copyright
© 2018 Noblett et al.
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