Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes.
Asian People
/ genetics
Case-Control Studies
China
/ epidemiology
Diabetes Mellitus, Type 2
/ physiopathology
Diabetic Nephropathies
/ epidemiology
Genetic Predisposition to Disease
Genotype
Humans
Incidence
Male
Methylenetetrahydrofolate Reductase (NADPH2)
/ genetics
Middle Aged
Polymorphism, Single Nucleotide
Smoking
/ adverse effects
Journal
Journal of human genetics
ISSN: 1435-232X
Titre abrégé: J Hum Genet
Pays: England
ID NLM: 9808008
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
03
07
2018
accepted:
17
10
2018
revised:
02
09
2018
pubmed:
7
11
2018
medline:
22
3
2019
entrez:
7
11
2018
Statut:
ppublish
Résumé
We investigated the interaction of MTHFR C677T polymorphism (rs1801133) with smoking in susceptibility to diabetic nephropathy (DN) in Chinese men with type 2 diabetes mellitus (T2DM). We studied 655 Chinese men with T2DM, who were divided into two groups (321 with DN and 334 without DN). The genotype of MTHFR C677T polymorphism was detected by real-time polymerase chain reaction. MTHFR TT genotype carried a higher risk of DN compared with the CC genotype (OR = 2.05; P = 0.002). The T allele showed marked association with DN development in patients who smoked, using additive, recessive, and dominant models (OR = 1.60, 1.83, and 1.88, respectively; P = 0.006, 0.002, and 0.04, respectively), which was not observed in the nonsmoking group. Patients with TT and CT genotypes, who smoked had a higher risk of DN compared with the control group (non-smoking with CC genotype; OR = 3.73 and 2.28, respectively; P < 0.001 and P = 0.004, respectively), whereas the other groups were not observed. In conclusion, the T allele of rs1801133 may be a risk factor for DN in Chinese men with T2DM, and synergy appears to exist between the MTHFR rs1801133 and smoking in susceptibility to DN.
Identifiants
pubmed: 30397262
doi: 10.1038/s10038-018-0531-y
pii: 10.1038/s10038-018-0531-y
doi:
Substances chimiques
MTHFR protein, human
EC 1.5.1.20
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-28Références
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