Growth Status, Inflammation, and Enteropathy in Young Children in Northern Tanzania.
Baths
Biomarkers
/ blood
Body Height
C-Reactive Protein
/ analysis
Case-Control Studies
Child, Preschool
Family Characteristics
Female
Growth Disorders
/ epidemiology
Humans
Hygiene
Infant
Inflammation
/ epidemiology
Intestinal Diseases
/ epidemiology
Male
Orosomucoid
/ analysis
Retrospective Studies
Tanzania
/ epidemiology
Water
alpha 1-Antitrypsin
/ blood
Journal
The American journal of tropical medicine and hygiene
ISSN: 1476-1645
Titre abrégé: Am J Trop Med Hyg
Pays: United States
ID NLM: 0370507
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
7
11
2018
medline:
17
10
2019
entrez:
7
11
2018
Statut:
ppublish
Résumé
Recent evidence suggests that enteropathy of the gut due to environmental conditions (i.e., environmental enteropathy [EE]) in young children is negatively associated with linear growth. Using a case-control study design, we examined the potential determinants of stunting in stunted and non-stunted children 22-28 months of age. Potential determinants included inflammation biomarkers C-reactive protein, alpha-1-acid glycoprotein (AGP), and endotoxin-core antibody (EndoCAb) measured in serum samples; enteropathy markers alpha-1-antitrypsin, neopterin, myeloperoxidase (MPO) measured in stools samples; and demographic, health, feeding, and household characteristics. We also explored the determinants of EE by testing associations of composite EE scores and individual biomarkers with potential risk factors. Fifty-two percent of children (
Identifiants
pubmed: 30398137
doi: 10.4269/ajtmh.17-0720
pmc: PMC6335920
doi:
Substances chimiques
Biomarkers
0
Orosomucoid
0
alpha 1-Antitrypsin
0
Water
059QF0KO0R
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-201Subventions
Organisme : World Health Organization
ID : 001
Pays : International
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