Quantification of Macrophages in High-Grade Gliomas by Using Ferumoxytol-enhanced MRI: A Pilot Study.

Adult Aged Brain Neoplasms / diagnostic imaging Female Ferrosoferric Oxide / therapeutic use Glioma / diagnostic imaging Humans Macrophages / cytology Magnetic Resonance Imaging / methods Male Middle Aged Pilot Projects Prospective Studies

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
01 2019
Historique:
pubmed: 7 11 2018
medline: 12 10 2019
entrez: 7 11 2018
Statut: ppublish

Résumé

Purpose To investigate ferumoxytol-enhanced MRI as a noninvasive imaging biomarker of macrophages in adults with high-grade gliomas. Materials and Methods In this prospective study, adults with high-grade gliomas were enrolled between July 2015 and July 2017. Each participant was administered intravenous ferumoxytol (5 mg/kg) and underwent 3.0-T MRI 24 hours later. Two sites in each tumor were selected for intraoperative sampling on the basis of the degree of ferumoxytol-induced signal change. Susceptibility and the relaxation rates R2* (1/T2*) and R2 (1/T2) were obtained by region-of-interest analysis by using the respective postprocessed maps. Each sample was stained with Prussian blue, CD68, CD163, and glial fibrillary acidic protein. Pearson correlation and linear mixed models were performed to assess the relationship between imaging measurements and number of 400× magnification high-power fields with iron-containing macrophages. Results Ten adults (four male participants [mean age, 65 years ± 9 {standard deviation}; age range, 57-74 years] and six female participants [mean age, 53 years ± 12 years; age range, 32-65 years]; mean age of all participants, 58 years ± 12 [age range, 32-74 years]) with high-grade gliomas were included. Significant positive correlations were found between susceptibility, R2*, and R2' and the number of high-power fields with CD163-positive (r range, 0.64-0.71; P < .01) and CD68-positive (r range, 0.55-0.57; P value range, .01-.02) iron-containing macrophages. No significant correlation was found between R2 and CD163-positive (r = 0.33; P = .16) and CD68-positive (r = 0.24; P = .32) iron-containing macrophages. Similar significance results were obtained with linear mixed models. At histopathologic analysis, iron particles were found only in macrophages; none was found in glial fibrillary acidic protein-positive tumor cells. Conclusion MRI measurements of susceptibility, R2*, and R2' (R2* - R2) obtained after ferumoxytol administration correlate with iron-containing macrophage concentration, and this shows their potential as quantitative imaging markers of macrophages in malignant gliomas. © RSNA, 2018 Online supplemental material is available for this article.

Identifiants

DOI: 10.1148/radiol.2018181204 PMID: 30398435 PMC: PMC6312434
pubmed: 30398435
doi: 10.1148/radiol.2018181204
pmc: PMC6312434
doi:

Substances chimiques

Ferrosoferric Oxide XM0M87F357

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

198-206

Subventions

Organisme : NCI NIH HHS
ID : P30 CA124435
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD081123
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA190196
Pays : United States

Références

Radiology. 2010 Nov;257(2):455-62
pubmed: 20843991
Clin Cancer Res. 2011 Sep 1;17(17):5695-704
pubmed: 21791632
Radiology. 2013 May;267(2):551-9
pubmed: 23315661
NMR Biomed. 2011 Nov;24(9):1129-36
pubmed: 21387445
PLoS One. 2012;7(8):e43339
pubmed: 22937035
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298418
Magn Reson Imaging. 2015 Jun;33(5):559-65
pubmed: 25721997
Neuroimage. 2012 Sep;62(3):1593-9
pubmed: 22634862
Oncotarget. 2017 Aug 7;8(42):72597-72612
pubmed: 29069812
Neuroimage. 2012 Feb 1;59(3):2560-8
pubmed: 21925276
Nature. 2017 May 25;545(7655):495-499
pubmed: 28514441
Jpn J Clin Oncol. 2008 Feb;38(2):140-2
pubmed: 18245515
Oncol Lett. 2018 Jan;15(1):998-1006
pubmed: 29399160
Nanomedicine. 2016 Aug;12(6):1535-42
pubmed: 27071335
Neuroimage Clin. 2017 Aug 24;16:429-438
pubmed: 28879084
Glia. 2011 Mar;59(3):472-85
pubmed: 21264953
Neuroimage. 2013 Jan 15;65:299-314
pubmed: 23036448
Neoplasia. 2017 Jan;19(1):1-7
pubmed: 27940247
Cancer Immunol Res. 2016 Mar;4(3):179-82
pubmed: 26701266
Contrast Media Mol Imaging. 2012 Jul-Aug;7(4):411-7
pubmed: 22649047
Radiology. 2000 Feb;214(2):568-74
pubmed: 10671613
Trends Ecol Evol. 2009 Mar;24(3):127-35
pubmed: 19185386
Nat Rev Cancer. 2004 Jan;4(1):71-8
pubmed: 14708027
Clin Cancer Res. 1999 May;5(5):1107-13
pubmed: 10353745

Auteurs

Michael Iv (M)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.
ORCID: 0000-0001-6794-7213

Peyman Samghabadi (P)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Samantha Holdsworth (S)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Andrew Gentles (A)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Paymon Rezaii (P)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.
ORCID: 0000-0002-4803-0853

Griffith Harsh (G)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Gordon Li (G)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Reena Thomas (R)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Michael Moseley (M)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Heike E Daldrup-Link (HE)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Hannes Vogel (H)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Max Wintermark (M)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Samuel Cheshier (S)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Kristen W Yeom (KW)

From the Departments of Radiology (M.I., P.R., H.E.D.L., M.W., K.W.Y.) and Pathology (P.S., H.V.), Stanford University Medical Center, 300 Pasteur Dr, Grant Building, Room S031E, Stanford, CA 94305; Richard M. Lucas Center for Imaging (S.H., M.M.) and Departments of Medicine (Biomedical Informatics Research) (A.G.), Neurosurgery (G.H., G.L., S.C.), and Neurology (Neuro-Oncology) (R.T.), Stanford University, Stanford, Calif.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Produits chimiques inorganiques › Minéraux › Oxyde ferrosoferrique › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Quantification of Macrophages in High-Grade...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Quantification of Macrophages in High-Grade...