Sex Hormones and Measures of Kidney Function in the Diabetes Prevention Program Outcomes Study.
Adult
Albuminuria
/ blood
Creatinine
/ urine
Cross-Sectional Studies
Diabetes Mellitus
/ epidemiology
Diabetic Nephropathies
/ blood
Disease Progression
Estradiol
/ blood
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Incidence
Kidney Function Tests
Male
Middle Aged
Overweight
/ complications
Sex Factors
Sex Hormone-Binding Globulin
/ analysis
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
09
07
2018
accepted:
30
10
2018
pubmed:
7
11
2018
medline:
28
1
2020
entrez:
7
11
2018
Statut:
ppublish
Résumé
Despite sex differences in chronic kidney disease (CKD) onset and progression, it is unclear whether endogenous sex hormones are associated with kidney function in persons without CKD. We conducted a secondary analysis of the Diabetes Prevention Program (DPP) and its follow-up observational study, the DPP Outcomes Study, over 11 years. Participants included overweight and glucose-intolerant men (n = 889) and pre- and postmenopausal women (n = 1281) not using exogenous sex hormones and whose urine albumin-to-creatinine ratio (ACR) was <30 mg/g and normal estimated glomerular filtration ratio (eGFR) was ≥60 mL/min/1.73 m2 at randomization. We examined the association between sex hormone levels and incidence of low eGFR and/or ACR ≥30 mg/g on at least one measurement. At randomization, the mean (SD) eGFR was 94 (15) mL/min/1.73 m2; the median ACR (interquartile range) was 4.5 (3.3 to 7.6) mg/g. During follow-up, 187 men (24.6%) and 263 women (24.2%) had incident albuminuria and 136 men (17.9%) and 123 women (11.3%) had incident low eGFR. Among men, higher baseline sex hormone-binding globulin (SHBG) level was associated with reduced low eGFR risk (hazard ratio per SD, 0.80; 95% CI, 0.57 to 0.90) in adjusted analyses. No significant associations were observed among women. There were significant interactions between sex steroid levels and low eGFR by randomization arm. Sex steroids were not associated with development of low eGFR or albuminuria. Among men, higher SHBG level was associated with reduced risk of low eGFR on at least one measurement.
Identifiants
pubmed: 30398516
pii: 5155462
doi: 10.1210/jc.2018-01495
pmc: PMC6391355
doi:
Substances chimiques
SHBG protein, human
0
Sex Hormone-Binding Globulin
0
Estradiol
4TI98Z838E
Creatinine
AYI8EX34EU
Banques de données
ClinicalTrials.gov
['NCT00038727']
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1171-1180Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK072041
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK094829
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK048489
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK053061
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK026687
Pays : United States
Informations de copyright
Copyright © 2019 Endocrine Society.
Références
Am J Kidney Dis. 2014 May;63(5):713-35
pubmed: 24647050
J Clin Endocrinol Metab. 2012 Aug;97(8):2853-61
pubmed: 22689695
J Clin Endocrinol Metab. 2017 Jan 1;102(1):33-39
pubmed: 27732332
Age Ageing. 2014 May;43(3):411-7
pubmed: 24321840
Hypertension. 2008 Apr;51(4):976-81
pubmed: 18259026
Clin Endocrinol (Oxf). 2009 Aug;71(2):246-52
pubmed: 19178534
Am J Kidney Dis. 2016 Nov;68(5):743-751
pubmed: 27555103
Hypertension. 1992 May;19(5):456-63
pubmed: 1568764
Nephrol Dial Transplant. 2009 Dec;24(12):3739-44
pubmed: 19574340
Mol Endocrinol. 2011 Feb;25(2):269-81
pubmed: 21193555
Basic Clin Androl. 2015 Dec 02;25:9
pubmed: 26635963
Horm Metab Res. 2009 May;41(5):356-62
pubmed: 19224431
J Clin Endocrinol Metab. 2017 Sep 1;102(9):3381-3389
pubmed: 28651370
Diabetes Res Clin Pract. 2003 Apr;60(1):33-9
pubmed: 12639763
Am J Kidney Dis. 2008 Mar;51(3):373-84
pubmed: 18295053
Gend Med. 2007 Mar;4(1):56-71
pubmed: 17584628
Kidney Int. 2011 Feb;79(4):404-13
pubmed: 20962747
Kidney Int. 2008 Aug;74(3):370-6
pubmed: 18496507
J Intern Med. 2010 Jun;267(6):612-20
pubmed: 20210838
Int J Obes (Lond). 2008 Oct;32(10):1537-44
pubmed: 18711387
Curr Cardiol Rep. 2014 Apr;16(4):467
pubmed: 24585109
J Am Soc Nephrol. 2003 Nov;14(11):2934-41
pubmed: 14569104
Kidney Int. 2007 Aug;72(4):464-72
pubmed: 17495854
Nat Rev Nephrol. 2009 Jul;5(7):384-96
pubmed: 19488070
Diabetes Care. 2009 Apr;32(4):720-5
pubmed: 19131464
Ann Intern Med. 2009 May 5;150(9):604-12
pubmed: 19414839
J Clin Endocrinol Metab. 2015 Oct;100(10):3778-86
pubmed: 26200237
Diabetes Care. 2005 Oct;28(10):2472-9
pubmed: 16186282
Menopause. 2011 Jun;18(6):629-37
pubmed: 21326121
J Clin Endocrinol Metab. 2014 Jun;99(6):2061-8
pubmed: 24628549
N Engl J Med. 2002 Feb 7;346(6):393-403
pubmed: 11832527
Diabetes Care. 2004 Dec;27(12):2893-7
pubmed: 15562203
Diabetes Care. 1999 Apr;22(4):623-34
pubmed: 10189543
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
J Clin Endocrinol Metab. 1999 Oct;84(10):3666-72
pubmed: 10523012
Clin Exp Hypertens. 1993 Jul;15(4):683-708
pubmed: 8374610
Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R794-9
pubmed: 16990489
Lancet Diabetes Endocrinol. 2015 Nov;3(11):866-75
pubmed: 26377054
BJOG. 2000 Aug;107(8):1017-21
pubmed: 10955435
Am J Kidney Dis. 2005 Jun;45(6):1019-25
pubmed: 15957130