An international perspective on hospitalized patients with viral community-acquired pneumonia.
Aged
Aged, 80 and over
Antiviral Agents
/ therapeutic use
Community-Acquired Infections
/ drug therapy
Cross-Sectional Studies
Databases, Factual
Female
Hospitalization
Humans
Influenza, Human
/ drug therapy
Internationality
Logistic Models
Male
Medication Adherence
Middle Aged
Oseltamivir
/ therapeutic use
Pneumonia, Viral
/ drug therapy
Prospective Studies
Community acquired pneumonia
Influenza
Oseltamivir
Testing
Viral pneumonia
Viral swab
Journal
European journal of internal medicine
ISSN: 1879-0828
Titre abrégé: Eur J Intern Med
Pays: Netherlands
ID NLM: 9003220
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
30
07
2018
revised:
14
10
2018
accepted:
24
10
2018
pubmed:
8
11
2018
medline:
5
6
2019
entrez:
8
11
2018
Statut:
ppublish
Résumé
Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
Sections du résumé
BACKGROUND
Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP.
METHODS
Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors.
RESULTS
553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%.
CONCLUSION
In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
Identifiants
pubmed: 30401576
pii: S0953-6205(18)30413-8
doi: 10.1016/j.ejim.2018.10.020
pmc: PMC7127340
pii:
doi:
Substances chimiques
Antiviral Agents
0
Oseltamivir
20O93L6F9H
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
54-70Investigateurs
Patricia Karina Aruj
(PK)
Silvia Attorri
(S)
Enrique Barimboim
(E)
Juan Pablo Caeiro
(JP)
María I Garzón
(MI)
Victor Hugo Cambursano
(VH)
Adrian Ceccato
(A)
Julio Chertcoff
(J)
Ariel Cordon Díaz
(A)
Lautaro de Vedia
(L)
Maria Cristina Ganaha
(MC)
Sandra Lambert
(S)
Gustavo Lopardo
(G)
Carlos M Luna
(CM)
Alessio Gerardo Malberti
(AG)
Nora Morcillo
(N)
Silvina Tartara
(S)
Claudia Pensotti
(C)
Betiana Pereyra
(B)
Pablo Gustavo Scapellato
(PG)
Juan Pablo Stagnaro
(JP)
Sonali Shah
(S)
Felix Lötsch
(F)
Florian Thalhammer
(F)
Kurt Anseeuw
(K)
Camille A Francois
(CA)
Eva Van Braeckel
(E)
Jean Louis Vincent
(JL)
Marcel Zannou Djimon
(MZ)
Simone Aranha Nouér
(S)
Peter Chipev
(P)
Milena Encheva
(M)
Darina Miteva
(D)
Diana Petkova
(D)
Adamou Dodo Balkissou
(AD)
Eric Walter Pefura Yone
(EW)
Bertrand Hugo Mbatchou Ngahane
(BH)
Ning Shen
(N)
Jin-Fu Xu
(JF)
Carlos Andres Bustamante Rico
(CA)
Ricardo Buitrago
(R)
Fernando Jose Pereira Paternina
(FJ)
Jean-Marie Kayembe Ntumba
(JM)
Vesna Vladic-Carevic
(V)
Marko Jakopovic
(M)
Zinka Matkovic
(Z)
Ivan Mitrecic
(I)
Marie-Laure Bouchy Jacobsson
(ML)
Anette Bro Christensen
(A)
Uffe Bødtger
(U)
Christian Niels Meyer
(CN)
Andreas Vestergaard Jensen
(A)
Ibrahim El-Said Abd El-Wahhab
(I)
Nesreen Elsayed Morsy
(N)
Hanaa Shafiek
(H)
Eman Sobh
(E)
Kedir Abdella Abdulsemed
(KA)
Fabrice Bertrand
(F)
Christian Brun-Buisson
(C)
Etienne de Montmollin
(E)
Muriel Fartoukh
(M)
Jonathan Messika
(J)
Pierre Tattevin
(P)
Abdo Khoury
(A)
Bernard Ebruke
(B)
Michael Dreher
(M)
Martin Kolditz
(M)
Matthias Meisinger
(M)
Mathias W Pletz
(MW)
Stefan Hagel
(S)
Jan Rupp
(J)
Tom Schaberg
(T)
Marc Spielmanns
(M)
Petra Creutz
(P)
Norton Suttorp
(N)
Beatrice Siaw-Lartey
(B)
Katerina Dimakou
(K)
Dimosthenis Papapetrou
(D)
Evdoxia Tsigou
(E)
Dimitrios Ampazis
(D)
Evangelos Kaimakamis
(E)
Mohit Bhatia
(M)
Raja Dhar
(R)
George D'Souza
(G)
Rajiv Garg
(R)
Parvaiz A Koul
(PA)
B S Jayaraj
(BS)
Kiran Vishnu Narayan
(KV)
Hirennappa B Udnur
(HB)
Shashi Bhaskara Krishnamurthy
(SB)
Surya Kant
(S)
Rajesh Swarnakar
(R)
Sundeep Salvi
(S)
Sneha Limaye
(S)
Keihan Golshani
(K)
Vera M Keatings
(VM)
Ignacio Martin-Loeches
(I)
Yasmin Maor
(Y)
Jacob Strahilevitz
(J)
Salvatore Battaglia
(S)
Maria Carrabba
(M)
Piero Ceriana
(P)
Marco Confalonieri
(M)
Antonella d'Arminio Monforte
(A)
Bruno Del Prato
(B)
Marino De Rosa
(M)
Riccardo Fantini
(R)
Giuseppe Fiorentino
(G)
Maria Antonia Gammino
(MA)
Francesco Menzella
(F)
Giuseppe Milani
(G)
Stefano Nava
(S)
Gerardo Palmiero
(G)
Roberta Petrino
(R)
Barbra Gabrielli
(B)
Paolo Rossi
(P)
Claudio Sorino
(C)
Gundi Steinhilber
(G)
Alessandro Zanforlin
(A)
Fabio Franzetti
(F)
Mauro Carone
(M)
Vincenzo Patella
(V)
Simone Scarlata
(S)
Andrea Comel
(A)
Kiyoyasu Kurahashi
(K)
Zeina Aoun Bacha
(Z)
Daniel Barajas Ugalde
(D)
Omar Ceballos Zuñiga
(O)
José F Villegas
(JF)
Milic Medenica
(M)
E M W van de Garde
(EMW)
Deebya Raj Mihsra
(D)
Poojan Shrestha
(P)
Elliott Ridgeon
(E)
Babatunde Ishola Awokola
(B)
Ogonna N O Nwankwo
(ONO)
Adefuye Bolanle Olufunlola
(AB)
Segaolu Olumide
(S)
Kingsley N Ukwaja
(KN)
Muhammad Irfan
(M)
Lukasz Minarowski
(L)
Skoczyński Szymon
(S)
Felipe Froes
(F)
Pedro Leuschner
(P)
Mariana Meireles
(M)
Cláudia Ferrão
(C)
Pedro Leuschner
(P)
João Neves
(J)
Sofia B Ravara
(SB)
Victoria Brocovschii
(V)
Chesov Ion
(C)
Doina Rusu
(D)
Cristina Toma
(C)
Daniela Chirita
(D)
Carmen Mihaela Dorobat
(CM)
Alexei Birkun
(A)
Anna Kaluzhenina
(A)
Abdullah Almotairi
(A)
Zakeya Abdulbaqi Ali Bukhary
(ZAA)
Jameela Edathodu
(J)
Amal Fathy
(A)
Abdullah Mushira Abdulaziz Enani
(A)
Nazik Eltayeb Mohamed
(N)
Jawed Ulhadi Memon
(J)
Abdelhaleem Bella
(A)
Nada Bogdanović
(N)
Branislava Milenkovic
(B)
Dragica Pesut
(D)
Luis Borderìas
(L)
Noel Manuel Bordon Garcia
(NM)
Hugo Cabello Alarcón
(H)
Catia Cilloniz
(C)
Antoni Torres
(A)
Vicens Diaz-Brito
(V)
Xavier Casas
(X)
Alicia Encabo González
(A)
Maria Luisa Fernández-Almira
(ML)
Miguel Gallego
(M)
Inmaculada Gaspar-GarcÍa
(I)
Juan González Del Castillo
(J)
Patricia Javaloyes Victoria
(P)
Elena Laserna Martínez
(E)
Rosa Malo de Molina
(R)
Rosario Menéndez
(R)
Ana Pando-Sandoval
(A)
Cristina Prat Aymerich
(C)
Alicia Lacoma de la Torre
(A)
Ignasi García-Olivé
(I)
Jordi Rello
(J)
Silvia Moyano
(S)
Francisco Sanz
(F)
Oriol Sibila
(O)
Ana Rodrigo-Troyano
(A)
Jordi Solé-Violán
(J)
Ane Uranga
(A)
Job F M van Boven
(JFM)
Ester Vendrell Torra
(E)
Jordi Almirall Pujol
(JA)
Charles Feldman
(C)
Ho Kee Yum
(H)
Arnauld Attannon Fiogbe
(AA)
Ferdaous Yangui
(F)
Semra Bilaceroglu
(S)
Levent Dalar
(L)
Ufuk Yilmaz
(U)
Artemii Bogomolov
(A)
Naheed Elahi
(N)
Devesh J Dhasmana
(DJ)
Andrew Feneley
(A)
Carole Hancock
(C)
Adam T Hill
(AT)
Banu Rudran
(B)
Silvia Ruiz-Buitrago
(S)
Marion Campbell
(M)
Paul Whitaker
(P)
Alexander Youzguin
(A)
Anika Singanayagam
(A)
Karen S Allen
(KS)
Veronica Brito
(V)
Jessica Dietz
(J)
Claire E Dysart
(CE)
Susan M Kellie
(SM)
Ricardo A Franco-Sadud
(RA)
Garnet Meier
(G)
Mina Gaga
(M)
Thomas L Holland
(TL)
Stephen P Bergin
(SP)
Fayez Kheir
(F)
Mark Landmeier
(M)
Manuel Lois
(M)
Girish B Nair
(GB)
Hemali Patel
(H)
Katherine Reyes
(K)
William Rodriguez-Cintron
(W)
Shigeki Saito
(S)
Nilam J Soni
(NJ)
Julio Noda
(J)
Cecilia I Hinojosa
(CI)
Stephanie M Levine
(SM)
Luis F Angel
(LF)
Antonio Anzueto
(A)
K Scott Whitlow
(K)
John Hipskind
(J)
Kunal Sukhija
(K)
Vicken Totten
(V)
Richard G Wunderink
(RG)
Ray D Shah
(RD)
Kondwelani John Mateyo
(KJ)
Manuela Carugati
(M)
Manuela Morosi
(M)
Elisa Monge
(E)
Informations de copyright
Copyright © 2018 European Federation of Internal Medicine. All rights reserved.
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