Intestinal helminth infection promotes IL-5- and CD4
Animals
Antigens, Helminth
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Cell Movement
Cells, Cultured
Coinfection
Cytotoxicity, Immunologic
Eosinophils
/ immunology
Female
Host-Parasite Interactions
Immunity
Interleukin-33
/ metabolism
Interleukin-5
/ metabolism
Lung
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Nematospiroides dubius
/ physiology
Nippostrongylus
/ physiology
Strongylida Infections
/ immunology
Trichuriasis
/ immunology
Trichuris
/ physiology
Journal
Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
13
08
2018
accepted:
03
10
2018
revised:
27
09
2018
pubmed:
8
11
2018
medline:
25
6
2019
entrez:
8
11
2018
Statut:
ppublish
Résumé
The ability of helminths to manipulate the immune system of their hosts to ensure their own survival is often credited with affecting responses to other pathogens. We undertook co-infection experiments in mice to determine how infection with the intestinal helminth Heligmosomoides polygyrus affected the parasitological, immunological and physiological outcomes of a primary infection with a distinct species of helminth; the lung migratory parasite Nippostrongylus brasiliensis. We found that migrating N. brasiliensis larvae were killed in the lungs of H. polygyrus-infected mice by a process involving IL-33-activated CD4
Identifiants
pubmed: 30401814
doi: 10.1038/s41385-018-0102-8
pii: S1933-0219(22)00383-X
doi:
Substances chimiques
Antigens, Helminth
0
Interleukin-33
0
Interleukin-5
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
352-362Références
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