The Regulation of Skin Fibrosis in Systemic Sclerosis by Extracellular ATP via P2Y
Adenosine Triphosphate
/ metabolism
Animals
Cells, Cultured
Endothelial Cells
/ metabolism
Fibroblasts
/ metabolism
Fibrosis
/ etiology
Humans
Immunoblotting
Interleukin-6
/ biosynthesis
Mice
Mice, Inbred C57BL
Receptors, Purinergic P2Y2
/ biosynthesis
Scleroderma, Systemic
/ complications
Signal Transduction
Skin
/ metabolism
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
09
05
2018
revised:
26
09
2018
accepted:
15
10
2018
pubmed:
8
11
2018
medline:
3
4
2020
entrez:
8
11
2018
Statut:
ppublish
Résumé
Tissue injury/hypoxia and oxidative stress induced-extracellular adenosine triphosphate (ATP) can act as damage-associated molecular pattern molecules, which initiate inflammatory response. Our objective was to elucidate the role of extracellular ATP in skin fibrosis in systemic sclerosis (SSc). We identified that hypoxia enhanced ATP release and that extracellular ATP enhanced IL-6 production more significantly in SSc fibroblasts than in normal fibroblasts. There were no significant differences of P2X and P2Y receptor expression levels between normal and SSc fibroblasts. Nonselective P2 receptor antagonist and selective P2Y
Identifiants
pubmed: 30404019
pii: S0022-202X(18)32791-X
doi: 10.1016/j.jid.2018.10.027
pii:
doi:
Substances chimiques
Interleukin-6
0
Receptors, Purinergic P2Y2
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
890-899Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.