A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles.
Adenoviridae
/ physiology
Animals
Chlorocebus aethiops
Cytoplasm
/ metabolism
Dengue Virus
/ physiology
Endosomes
/ metabolism
HEK293 Cells
Humans
Membrane Fusion
/ drug effects
Scorpion Venoms
/ chemistry
Scorpions
/ chemistry
Sendai virus
/ physiology
Vero Cells
Virus Internalization
/ drug effects
Zika virus
antiviral agent
antiviral mechanism
antiviral peptide
dengue virus
dengue virus (DENV)
endosome
hepatitis C virus (HCV)
herpes simplex virus
infection
membrane fusion
peptides
scorpion venom peptide
virus entry
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 01 2019
04 01 2019
Historique:
received:
23
07
2018
revised:
01
11
2018
pubmed:
9
11
2018
medline:
10
4
2019
entrez:
9
11
2018
Statut:
ppublish
Résumé
Viral infections still threaten human health all over the world, and many people die from viral diseases every year. However, there are no effective vaccines or drugs for preventing or managing most viral diseases. Thus, the discovery and development of broad-spectrum antiviral agents remain urgent. Here, we expressed and purified a venom peptide, Ev37, from the scorpion
Identifiants
pubmed: 30404919
pii: S0021-9258(20)36889-7
doi: 10.1074/jbc.RA118.005015
pmc: PMC6322876
pii:
doi:
Substances chimiques
Scorpion Venoms
0
Banques de données
PDB
['5IPO']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
182-194Informations de copyright
© 2019 Li et al.
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