Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer.
Animals
Antineoplastic Agents, Phytogenic
/ administration & dosage
Carcinoma, Pancreatic Ductal
/ drug therapy
Cell Line, Tumor
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Coumarins
/ administration & dosage
Humans
Lythraceae
/ chemistry
Mice
Pancreatic Neoplasms
/ drug therapy
Phosphatidylinositol 3-Kinases
/ metabolism
Phosphorylation
/ drug effects
Proto-Oncogene Proteins c-akt
/ metabolism
Signal Transduction
/ drug effects
TOR Serine-Threonine Kinases
/ metabolism
Xenograft Model Antitumor Assays
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
01
05
2018
revised:
06
09
2018
accepted:
29
10
2018
pubmed:
9
11
2018
medline:
26
11
2019
entrez:
9
11
2018
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy and is highly resistant to standard treatment regimens. Targeted therapies against
Identifiants
pubmed: 30404927
pii: 1535-7163.MCT-18-0464
doi: 10.1158/1535-7163.MCT-18-0464
pmc: PMC6363854
mid: NIHMS1511720
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Coumarins
0
3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
1143-70-0
MTOR protein, human
EC 2.7.1.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-311Subventions
Organisme : NCI NIH HHS
ID : R01 CA161976
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA209536
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA216090
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA211034
Pays : United States
Informations de copyright
©2018 American Association for Cancer Research.
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