Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease.
IPSC
PD
mitochondrial dysfunction
oxidative stress
therapeutics
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
03
07
2018
revised:
11
10
2018
accepted:
22
10
2018
pubmed:
9
11
2018
medline:
23
6
2020
entrez:
9
11
2018
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the second most common neurodegenerative disease. Two percent of the population above the age of 60 is affected by the disease. The pathological hallmarks of PD include loss of dopaminergic neurons and the presence of Lewy bodies. Mitochondrial dysfunction and oxidative stress are thought to play a pivotal role in both sporadic and familial forms of the disease. In this review we focus on the role of mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell (IPSC) models of PD.We also provide an overview of therapeutics that have been tested and some possible new therapeutics that can be tested in IPSC models of PD.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-532Subventions
Organisme : The Cure Parkinson's Trust
Pays : International
Informations de copyright
© 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.