Peripheral Blood DNA Methylation as Potential Biomarker of Malignant Pleural Mesothelioma in Asbestos-Exposed Subjects.

Aged Asbestos / adverse effects Biomarkers, Tumor / blood Carcinogens / toxicity Case-Control Studies DNA / blood DNA Methylation Female Follow-Up Studies Humans Lung Neoplasms / blood Male Mesothelioma / blood Mesothelioma, Malignant Occupational Exposure / adverse effects Pleural Neoplasms / blood Prognosis ROC Curve
Asbestos exposure Case-control discrimination DNA-methylation Early biomarker Malignant pleural mesothelioma

Journal

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
ISSN: 1556-1380
Titre abrégé: J Thorac Oncol
Pays: United States
ID NLM: 101274235

Informations de publication

Date de publication:
03 2019
Historique:
received: 20 02 2018
revised: 02 10 2018
accepted: 27 10 2018
pubmed: 9 11 2018
medline: 17 4 2020
entrez: 9 11 2018
Statut: ppublish

Résumé

Malignant pleural mesothelioma (MPM) is an aggressive tumor strongly associated with asbestos exposure. Patients are usually diagnosed when current treatments have limited benefits, highlighting the need for noninvasive early diagnostic tests to monitor asbestos-exposed people. We used a genome-wide methylation array to identify, in asbestos-exposed subjects, novel blood DNA methylation markers of MPM in 163 MPM cases and 137 cancer-free controls (82 MPM cases and 68 controls, training set; replication in 81 MPM cases and 69 controls, test set) sampled from the same areas. Evidence of differential methylation between MPM cases and controls was found (more than 800 cytosine-guanine dinucleotide sites, false discovery rate p value (p We identified signatures of differential methylation in DNA from whole blood between asbestos exposed MPM cases and controls. Our results provide the rationale to further investigate, in prospective studies, the potential use of blood DNA methylation profiles for the identification of early changes related to the MPM carcinogenic process.

Identifiants

DOI: 10.1016/j.jtho.2018.10.163 PMID: 30408567
pubmed: 30408567
pii: S1556-0864(18)33412-9
doi: 10.1016/j.jtho.2018.10.163
pii:
doi:

Substances chimiques

Biomarkers, Tumor 0
Carcinogens 0
Asbestos 1332-21-4
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

527-539

Informations de copyright

Copyright © 2018 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Auteurs

Simonetta Guarrera (S)

Italian Institute for Genomic Medicine, IIGM, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.

Clara Viberti (C)

Italian Institute for Genomic Medicine, IIGM, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.

Giovanni Cugliari (G)

Italian Institute for Genomic Medicine, IIGM, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.

Alessandra Allione (A)

Italian Institute for Genomic Medicine, IIGM, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.

Elisabetta Casalone (E)

Italian Institute for Genomic Medicine, IIGM, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.

Marta Betti (M)

Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.

Daniela Ferrante (D)

Medical Statistics and Cancer Epidemiology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; Cancer Epidemiology Unit, CPO-Piemonte, Novara, Italy.

Anna Aspesi (A)

Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.

Caterina Casadio (C)

Thoracic Surgery Unit, AOU Maggiore Della Carità, Novara, Italy.

Federica Grosso (F)

Division of Medical Oncology, SS. Antonio e Biagio General Hospital, Alessandria, Italy.

Roberta Libener (R)

Pathology Unit, SS. Antonio e Biagio General Hospital, Alessandria, Italy.

Ezio Piccolini (E)

Pneumology Unit, Santo Spirito Hospital, Casale Monferrato (AL), Italy.

Dario Mirabelli (D)

Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy; Cancer Epidemiology Unit, CPO Piemonte, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates "G. Scansetti," University of Turin, Turin, Italy.

Irma Dianzani (I)

Department of Health Sciences, University of Piemonte Orientale, Novara, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates "G. Scansetti," University of Turin, Turin, Italy.

Corrado Magnani (C)

Medical Statistics and Cancer Epidemiology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy; Cancer Epidemiology Unit, CPO-Piemonte, Novara, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates "G. Scansetti," University of Turin, Turin, Italy.

Giuseppe Matullo (G)

Italian Institute for Genomic Medicine, IIGM, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy; Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates "G. Scansetti," University of Turin, Turin, Italy; Medical Genetics Unit, AOU Città della Salute e della Scienza, Turin, Italy. Electronic address: giuseppe.matullo@unito.it.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Acide silicique › Silicates › Amiante › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Cancérogènes › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs mésotheliales › Mésothéliome › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs de la plèvre › Mésothéliome malin › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition professionnelle › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs de la plèvre › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Diagnostic › Pronostic › Peripheral Blood DNA Methylation as Potential...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Courbe ROC › Peripheral Blood DNA Methylation as Potential...