Danhong injection in cardiovascular and cerebrovascular diseases: Pharmacological actions, molecular mechanisms, and therapeutic potential.
Atherosclerosis
Cardiac hypertrophy
Cardiovascular diseases
Coronary artery disease
Danhong injection
Danshensu (PubChem CID: 11600642)
Ferulic acid (PubChem CID: 445858)
Hydroxysafflor yellow A (PubChem CID: 6443665)
Protocatechuic aldehyde (PubChem CID: 8768)
Rosmarinic acid (PubChem CID: 5281792)
Salvianolic acid A (PubChem CID: 5281793)
Salvianolic acid B (PubChem CID: 11629084)
Salvianolic acid D (PubChem CID: 75412558)
Stroke
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
01
08
2018
revised:
01
11
2018
accepted:
04
11
2018
pubmed:
9
11
2018
medline:
14
5
2019
entrez:
9
11
2018
Statut:
ppublish
Résumé
Cardiovascular and cerebrovascular diseases are the main cause of mortality worldwide, currently with less than optimum therapeutic options. Danhong injection (DHI) is a medicinal preparation based on two eminent Chinese herbal medicines, Salviae Miltiorrhizae (Dan Shen; family: Lamiaceae) and Flos Carthami (Hong Hua; family: Compositae/Asteraceae). DHI has been mainly used in the clinical therapy of cardiovascular (such as acute coronary syndrome and angina pectoris) and cerebrovascular diseases (such as stroke) in China for many years. The pharmacological properties of DHI include anti-inflammatory, anti-oxidant, anti-coagulatory, hypolipidemic, anti-apoptotic, vasodilatory, and angiogenesis-promoting actions. DHI offers a safe and effective therapeutic agent against cardiovascular and cerebrovascular diseases by modulating multiple disease-relevant signaling pathways and molecular targets. Herein, we provide a comprehensive review of the phytochemistry, therapeutic effects, molecular mechanisms, and adverse reactions of DHI in cardiovascular and cerebrovascular diseases. We also highlight the latest pharmacological advances and therapeutic potential of this promising herb-derived cardiovascular drug preparation.
Identifiants
pubmed: 30408571
pii: S1043-6618(18)30856-9
doi: 10.1016/j.phrs.2018.11.006
pii:
doi:
Substances chimiques
Drugs, Chinese Herbal
0
danhong
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-75Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.