Reversing multi-drug tumor resistance to Paclitaxel by well-defined pH-sensitive amphiphilic polypeptide block copolymers via induction of lysosomal membrane permeabilization.
Antineoplastic Agents, Phytogenic
/ pharmacology
Breast Neoplasms
/ drug therapy
Cell Membrane Permeability
/ drug effects
Drug Carriers
Drug Delivery Systems
Drug Resistance, Neoplasm
Female
Humans
Hydrogen-Ion Concentration
Lysosomes
/ metabolism
Paclitaxel
/ chemistry
Peptide Fragments
/ chemistry
Polymers
/ chemistry
Tumor Cells, Cultured
Uterine Neoplasms
/ drug therapy
Lysosomal membrane permeability
Paclitaxel
Polypeptide hybrid copolymers
Tumor resistance
pH sensitive
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
01 Feb 2019
01 Feb 2019
Historique:
received:
11
06
2018
revised:
18
10
2018
accepted:
24
10
2018
pubmed:
9
11
2018
medline:
14
6
2019
entrez:
9
11
2018
Statut:
ppublish
Résumé
A series of hybrid di-block copolymers of poly(l- glutamic acid-b-l- leucine) (PGA-PLeu), methoxy poly (ethylene glycol)-b-poly(l-leucine) (PEG-PLeu), methoxy poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamic acid) (PEG-PBLG) and tri-block copolymers of poly(ethylene glycol)-b-poly(l-glutamic acid-co-null
Identifiants
pubmed: 30408674
pii: S0927-7765(18)30765-3
doi: 10.1016/j.colsurfb.2018.10.072
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Drug Carriers
0
Peptide Fragments
0
Polymers
0
Paclitaxel
P88XT4IS4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-27Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.