Pathogenesis of idiopathic Normal Pressure Hydrocephalus: A review of knowledge.

Female Humans Hydrocephalus, Normal Pressure / cerebrospinal fluid Male
Idiopathic Literature review Normal pressure hydrocephalus Pathogenesis Physiopathology

Journal

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 10 07 2018
accepted: 29 10 2018
pubmed: 10 11 2018
medline: 2 4 2019
entrez: 10 11 2018
Statut: ppublish

Résumé

Idiopathic Normal Pressure Hydrocephalus (iNPH) is a frequent neuropsychiatric entity. Clinically it is characterised by Hakim's triad: Dementia, gait disturbance and urinary incontinence. While its symptomatology is typical, the etiology and thereby physiopathology of iNPH still remain enigmatic. This review summarizes and synthesizes different etiologic conceptions and physiopathologic aspects of iNPH. A research of literature via the PubMed/MEDLINE and the Cochrane database was conducted. Only English language articles clearly outlining a reasonable concept of physiopathology were included. Most authors advocate that iNPH is a result of chronically altered cerebrospinal fluid (CSF) dynamics, i.e. deranged CSF production, kinetics and reabsorption. In addition, there are vascular, metabolo-neurodegenerative and hereditary factors. Neuroinflammation does not seem to play a significant role in the etiology of iNPH. All in all, iNPH seems to combine several pathogenetic factors leading to a self-reinforcing vicious circle. The majority of studies hint at CSF disturbances on grounds of altered hemodynamics.

Identifiants

DOI: 10.1016/j.jocn.2018.10.147 PMID: 30409528
pubmed: 30409528
pii: S0967-5868(18)31193-7
doi: 10.1016/j.jocn.2018.10.147
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

10-13

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Konstantin Bräutigam (K)

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: konstantin.braeutigam@charite.de.

Antonis Vakis (A)

Department of Neurosurgery, University of Crete, Panepistimiou, 71500 Iraklio, Greece.

Christos Tsitsipanis (C)

Department of Neurosurgery, University of Crete, Panepistimiou, 71500 Iraklio, Greece.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pathogenesis of idiopathic Normal Pressure...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Hydrocéphalie › Hydrocéphalie chronique de l'adulte › Pathogenesis of idiopathic Normal Pressure...