MERS coronavirus outbreak: Implications for emerging viral infections.
Coronavirus
Infection
MERS
Middle East
Respiratory
Saudi Arabia
Transmission
Journal
Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
21
07
2018
revised:
28
09
2018
accepted:
11
10
2018
pubmed:
11
11
2018
medline:
13
4
2019
entrez:
11
11
2018
Statut:
ppublish
Résumé
In September 2012, a novel coronavirus was isolated from a patient who died in Saudi Arabia after presenting with acute respiratory distress and acute kidney injury. Analysis revealed the disease to be due to a novel virus which was named Middle East Respiratory Coronavirus (MERS-CoV). There have been several MERS-CoV hospital outbreaks in KSA, continuing to the present day, and the disease has a mortality rate in excess of 35%. Since 2012, the World Health Organization has been informed of 2220 laboratory-confirmed cases resulting in at least 790 deaths. Cases have since arisen in 27 countries, including an outbreak in the Republic of Korea in 2015 in which 36 people died, but more than 80% of cases have occurred in Saudi Arabia.. Human-to-human transmission of MERS-CoV, particularly in healthcare settings, initially caused a 'media panic', however human-to-human transmission appears to require close contact and thus far the virus has not achieved epidemic potential. Zoonotic transmission is of significant importance and evidence is growing implicating the dromedary camel as the major animal host in spread of disease to humans. MERS-CoV is now included on the WHO list of priority blueprint diseases for which there which is an urgent need for accelerated research and development as they have the potential to cause a public health emergency while there is an absence of efficacious drugs and/or vaccines. In this review we highlight epidemiological, clinical, and infection control aspects of MERS-CoV as informed by the Saudi experience. Attention is given to recommended treatments and progress towards vaccine development.
Identifiants
pubmed: 30413355
pii: S0732-8893(18)30502-9
doi: 10.1016/j.diagmicrobio.2018.10.011
pmc: PMC7127703
pii:
doi:
Substances chimiques
Antiviral Agents
0
Viral Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-285Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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