Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data.
Aged
Aged, 80 and over
Brain
/ diagnostic imaging
Brain Ischemia
/ diagnostic imaging
Endovascular Procedures
Female
Fibrinolytic Agents
/ therapeutic use
Humans
Magnetic Resonance Imaging
Middle Aged
Neuroimaging
Perfusion Imaging
Stroke
/ diagnostic imaging
Thrombectomy
/ methods
Tissue Plasminogen Activator
/ therapeutic use
Tomography, X-Ray Computed
Treatment Outcome
Journal
The Lancet. Neurology
ISSN: 1474-4465
Titre abrégé: Lancet Neurol
Pays: England
ID NLM: 101139309
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
08
04
2018
revised:
15
08
2018
accepted:
15
08
2018
pubmed:
11
11
2018
medline:
6
5
2020
entrez:
11
11
2018
Statut:
ppublish
Résumé
CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome and whether they interacted with the treatment effect of endovascular thrombectomy on functional outcome. In this systematic review and meta-analysis, the HERMES collaboration pooled patient-level data from all randomised controlled trials that compared endovascular thrombectomy (predominantly using stent retrievers) with standard medical therapy in patients with anterior circulation ischaemic stroke, published in PubMed from Jan 1, 2010, to May 31, 2017. The primary endpoint was functional outcome, assessed by the modified Rankin Scale (mRS) at 90 days after stroke. Ischaemic core was estimated, before treatment with either endovascular thrombectomy or standard medical therapy, by CTP as relative cerebral blood flow less than 30% of normal brain blood flow or by MRI as an apparent diffusion coefficient less than 620 μm We identified seven studies with 1764 patients, all of which were included in the meta-analysis. CTP was available and assessable for 591 (34%) patients and diffusion MRI for 309 (18%) patients. Functional independence was worse in patients who had CTP versus those who had diffusion MRI, after adjustment for ischaemic core volume (odds ratio [OR] 0·47 [95% CI 0·30-0·72], p=0·0007), so the imaging modalities were not pooled. Increasing ischaemic core volume was associated with reduced likelihood of functional independence (CTP OR 0·77 [0·69-0·86] per 10 mL, p Estimated ischaemic core volume was independently associated with functional independence and functional improvement but did not modify the treatment benefit of endovascular thrombectomy over standard medical therapy for improved functional outcome. Combining ischaemic core volume with age and expected imaging-to-reperfusion time will improve assessment of prognosis and might inform endovascular thrombectomy treatment decisions. Medtronic.
Sections du résumé
BACKGROUND
CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome and whether they interacted with the treatment effect of endovascular thrombectomy on functional outcome.
METHODS
In this systematic review and meta-analysis, the HERMES collaboration pooled patient-level data from all randomised controlled trials that compared endovascular thrombectomy (predominantly using stent retrievers) with standard medical therapy in patients with anterior circulation ischaemic stroke, published in PubMed from Jan 1, 2010, to May 31, 2017. The primary endpoint was functional outcome, assessed by the modified Rankin Scale (mRS) at 90 days after stroke. Ischaemic core was estimated, before treatment with either endovascular thrombectomy or standard medical therapy, by CTP as relative cerebral blood flow less than 30% of normal brain blood flow or by MRI as an apparent diffusion coefficient less than 620 μm
FINDINGS
We identified seven studies with 1764 patients, all of which were included in the meta-analysis. CTP was available and assessable for 591 (34%) patients and diffusion MRI for 309 (18%) patients. Functional independence was worse in patients who had CTP versus those who had diffusion MRI, after adjustment for ischaemic core volume (odds ratio [OR] 0·47 [95% CI 0·30-0·72], p=0·0007), so the imaging modalities were not pooled. Increasing ischaemic core volume was associated with reduced likelihood of functional independence (CTP OR 0·77 [0·69-0·86] per 10 mL, p
INTERPRETATION
Estimated ischaemic core volume was independently associated with functional independence and functional improvement but did not modify the treatment benefit of endovascular thrombectomy over standard medical therapy for improved functional outcome. Combining ischaemic core volume with age and expected imaging-to-reperfusion time will improve assessment of prognosis and might inform endovascular thrombectomy treatment decisions.
FUNDING
Medtronic.
Identifiants
pubmed: 30413385
pii: S1474-4422(18)30314-4
doi: 10.1016/S1474-4422(18)30314-4
pii:
doi:
Substances chimiques
Fibrinolytic Agents
0
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Comparative Study
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-55Subventions
Organisme : Department of Health
ID : HTA/14/08/47
Pays : United Kingdom
Investigateurs
Olvert A Berkhemer
(OA)
Puck Ss Fransen
(PS)
Debbie Beumer
(D)
Lucie A van den Berg
(LA)
Hester F Lingsma
(HF)
Albert J Yoo
(AJ)
Wouter J Schonewille
(WJ)
Jan Albert Vos
(JA)
Paul J Nederkoorn
(PJ)
Marieke Jh Wermer
(MJ)
Marianne Aa van Walderveen
(MA)
Julie Staals
(J)
Jeannette Hofmeijer
(J)
Jacques A van Oostayen
(JA)
Geert J Lycklama À Nijeholt
(GJ)
Jelis Boiten
(J)
Patrick A Brouwer
(PA)
Bart J Emmer
(BJ)
Sebastiaan F de Bruijn
(SF)
Lukas C van Dijk
(LC)
Jaap Kappelle
(J)
Rob H Lo
(RH)
Ewoud J van Dijk
(EJ)
Joost de Vries
(J)
Paul L M de Kort
(PLM)
Willem Jan J van Rooij
(WJJ)
Jan S P van den Berg
(JSP)
Boudewijn A A M van Hasselt
(BAAM)
Leo A M Aerden
(LAM)
René J Dallinga
(RJ)
Marieke C Visser
(MC)
Joseph C J Bot
(JCJ)
Patrick C Vroomen
(PC)
Omid Eshghi
(O)
Tobien H C M L Schreuder
(THCML)
Roel J J Heijboer
(RJJ)
Koos Keizer
(K)
Alexander V Tielbeek
(AV)
Heleen M den Hertog
(HM)
Dick G Gerrits
(DG)
Renske M van den Berg-Vos
(RM)
Giorgos B Karas
(GB)
Ewout W Steyerberg
(EW)
Zwenneke Flach
(Z)
Henk A Marquering
(HA)
Marieke E S Sprengers
(MES)
Sjoerd F M Jenniskens
(SFM)
Ludo F M Beenen
(LFM)
René van den Berg
(R)
Peter J Koudstaal
(PJ)
Wim H van Zwam
(WH)
Yvo B W E M Roos
(YBWEM)
Aad van der Lugt
(A)
Robert J van Oostenbrugge
(RJ)
Charles B L M Majoie
(CBLM)
Diederik W J Dippel
(DWJ)
Martin M Brown
(MM)
Thomas Liebig
(T)
Theo Stijnen
(T)
Tommy Andersson
(T)
Heinrich Mattle
(H)
Nils Wahlgren
(N)
Esther van der Heijden
(E)
Naziha Ghannouti
(N)
Nadine Fleitour
(N)
Imke Hooijenga
(I)
Corina Puppels
(C)
Wilma Pellikaan
(W)
Annet Geerling
(A)
Annemieke Lindl-Velema
(A)
Gina van Vemde
(G)
Ans de Ridder
(A)
Paut Greebe
(P)
José de Bont-Stikkelbroeck
(J)
Joke de Meris
(J)
Kirsten Janssen
(K)
Willy Struijk
(W)
Silvan Licher
(S)
Nikki Boodt
(N)
Adriaan Ros
(A)
Esmee Venema
(E)
Ilse Slokkers
(I)
Raymie-Jayce Ganpat
(RJ)
Maxim Mulder
(M)
Nawid Saiedie
(N)
Alis Heshmatollah
(A)
Stefanie Schipperen
(S)
Stefan Vinken
(S)
Tiemen van Boxtel
(T)
Jeroen Koets
(J)
Merel Boers
(M)
Emilie Santos
(E)
Jordi Borst
(J)
Ivo Jansen
(I)
Manon Kappelhof
(M)
Marit Lucas
(M)
Ralph Geuskens
(R)
Renan Sales Barros
(RS)
Roeland Dobbe
(R)
Marloes Csizmadia
(M)
M D Hill
(MD)
M Goyal
(M)
A M Demchuk
(AM)
B K Menon
(BK)
M Eesa
(M)
K J Ryckborst
(KJ)
M R Wright
(MR)
N R Kamal
(NR)
L Andersen
(L)
P A Randhawa
(PA)
T Stewart
(T)
S Patil
(S)
P Minhas
(P)
M Almekhlafi
(M)
S Mishra
(S)
F Clement
(F)
T Sajobi
(T)
A Shuaib
(A)
W J Montanera
(WJ)
D Roy
(D)
F L Silver
(FL)
T G Jovin
(TG)
D F Frei
(DF)
B Sapkota
(B)
J L Rempel
(JL)
J Thornton
(J)
D Williams
(D)
D Tampieri
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A Y Poppe
(AY)
D Dowlatshahi
(D)
J H Wong
(JH)
A P Mitha
(AP)
S Subramaniam
(S)
G Hull
(G)
M W Lowerison
(MW)
T Sajobi
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M Salluzzi
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(MR)
M Maxwell
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E Drupals
(E)
K Armitage
(K)
P A Barber
(PA)
E E Smith
(EE)
W F Morrish
(WF)
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(SB)
C Derdeyn
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(B)
D Yavagal
(D)
R Martin
(R)
R Brant
(R)
Y Yu
(Y)
R A Willinsky
(RA)
W J Montanera
(WJ)
A Weill
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C Kenney
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H Aram
(H)
T Stewart
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P K Stys
(PK)
T W Watson
(TW)
G Klein
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D Pearson
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P Couillard
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D Singh
(D)
E Klourfeld
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O Imoukhuede
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P Choi
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M Horton
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(TS)
J Desai
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J H Wong
(JH)
A P Mitha
(AP)
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(NJ)
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A Moore
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(O)
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M O'Donnell
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J Harbison
(J)
P McElwaine
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K Mulpeter
(K)
C McLoughlin
(C)
M Reardon
(M)
E Harkin
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E Dolan
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M Watts
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N Cunningham
(N)
C Fallon
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S Gallagher
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P Cotter
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M Crowe
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R Doyle
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I Noone
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M Hammer
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M Starr
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L Wechsler
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S Streib
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F L Silver
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J Williams
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R Wiegner
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L K Casaubon
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C Jaigobin
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J M Del Campo
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E Elamin
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J D Schaafsma
(JD)
R A Willinsky
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R Agid
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R Farb
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B L Sapkoda
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B W Baxter
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K Barton
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A Knox
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A Porter
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A Sirelkhatim
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C Dellinger
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J Wagner
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I Chang
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B Spencer
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G Dooley
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N Campbell
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M Cortes
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M Hogan
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G Basir
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H Lesiuk
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M Santos
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H Choe
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D C Weisman
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B Klein
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A Hunter
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Peter J Mitchell
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Heinrich P Mattle
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T Devlin
(T)
B Baxter
(B)
H Hawk
(H)
B Sapkota
(B)
S Quarfordt
(S)
A Sirelkhatim
(A)
C Dellinger
(C)
K Barton
(K)
V K Reddy
(VK)
A Ducruet
(A)
A Jadhav
(A)
A Horev
(A)
D-V Giurgiutiu
(DV)
V Totoraitis
(V)
M Hammer
(M)
B Jankowitz
(B)
L Wechsler
(L)
M Rocha
(M)
D Gulati
(D)
D Campbell
(D)
M Star
(M)
L Baxendell
(L)
J Oakley
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K Snyder
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G Gascou
(G)
M Moynier
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O Singer
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Emelda Veraque
(E)
Louise Harrison
(L)
Rekha Keshvara
(R)
James Cunningham
(J)
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