Four Unique Interneuron Populations Reside in Neocortical Layer 1.
barrel cortex
interneurons
layer 1
neocortex
top-down modulation
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
27
06
2018
revised:
05
10
2018
accepted:
29
10
2018
pubmed:
11
11
2018
medline:
17
10
2019
entrez:
11
11
2018
Statut:
ppublish
Résumé
Sensory perception depends on neocortical computations that contextually adjust sensory signals in different internal and environmental contexts. Neocortical layer 1 (L1) is the main target of cortical and subcortical inputs that provide "top-down" information for context-dependent sensory processing. Although L1 is devoid of excitatory cells, it contains the distal "tuft" dendrites of pyramidal cells (PCs) located in deeper layers. L1 also contains a poorly characterized population of GABAergic interneurons (INs), which regulate the impact that different top-down inputs have on PCs. A poor comprehension of L1 IN subtypes and how they affect PC activity has hampered our understanding of the mechanisms that underlie contextual modulation of sensory processing. We used novel genetic strategies in male and female mice combined with electrophysiological and morphological methods to help resolve differences that were unclear when using only electrophysiological and/or morphological approaches. We discovered that L1 contains four distinct populations of INs, each with a unique molecular profile, morphology, and electrophysiology, including a previously overlooked IN population (named here "canopy cells") representing 40% of L1 INs. In contrast to what is observed in other layers, most L1 neurons appear to be unique to the layer, highlighting the specialized character of the signal processing that takes place in L1. This new understanding of INs in L1, as well as the application of genetic methods based on the markers described here, will enable investigation of the cellular and circuit mechanisms of top-down processing in L1 with unprecedented detail.
Identifiants
pubmed: 30413647
pii: JNEUROSCI.1613-18.2018
doi: 10.1523/JNEUROSCI.1613-18.2018
pmc: PMC6325270
doi:
Substances chimiques
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
125-139Subventions
Organisme : NINDS NIH HHS
ID : F31 NS106793
Pays : United States
Organisme : NIMH NIH HHS
ID : UG3 MH120096
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH071679
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS081297
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH096331
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS074972
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 the authors 0270-6474/19/390125-15$15.00/0.
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