Anti-inflammatory and analgesic activity of Habbe Gule Aakh, A polyherbal Unani formulation in animal models.
Acetic acid
Habbe Gule Aakh
Histamine
Inflammation
Pain
Unani medicine
Writhing
Journal
Journal of Ayurveda and integrative medicine
ISSN: 0975-9476
Titre abrégé: J Ayurveda Integr Med
Pays: United States
ID NLM: 101551404
Informations de publication
Date de publication:
Historique:
received:
12
07
2017
revised:
18
12
2017
accepted:
16
01
2018
pubmed:
12
11
2018
medline:
12
11
2018
entrez:
12
11
2018
Statut:
ppublish
Résumé
Habbe Gule Aakh is extensively used in Unani medicine for anti-inflammatory and analgesic activity. To evaluate anti-inflammatory and analgesic effects of Habbe Gule Aakh on Wistar rats and Swiss mice of either sex. The study was carried out in Wistar rats for anti-inflammatory activity while Swiss mice were used for analgesic activity. In both the tests animals were divided into five groups of six animals each which served as control, standard and test groups A, B and C. For anti-inflammatory activity, method reported by Amman was followed. For analgesic activity, Koster's protocol was adapted. Significant (P < 0.01) reduction in the paw volume was noted in all the test groups but less than the standard drug. Mean writhes of group B and C reduced significantly (P < 0.01) demonstrating analgesic effect. The study validated the claim of Unani medicine of use of Habbe Gule Aakh in inflammation and pain. Further, phytochemical studies are needed to know the exact mechanism of action of this formulation.
Sections du résumé
BACKGROUND
BACKGROUND
Habbe Gule Aakh is extensively used in Unani medicine for anti-inflammatory and analgesic activity.
OBJECTIVE
OBJECTIVE
To evaluate anti-inflammatory and analgesic effects of Habbe Gule Aakh on Wistar rats and Swiss mice of either sex.
MATERIALS AND METHODS
METHODS
The study was carried out in Wistar rats for anti-inflammatory activity while Swiss mice were used for analgesic activity. In both the tests animals were divided into five groups of six animals each which served as control, standard and test groups A, B and C. For anti-inflammatory activity, method reported by Amman was followed. For analgesic activity, Koster's protocol was adapted.
RESULTS
RESULTS
Significant (P < 0.01) reduction in the paw volume was noted in all the test groups but less than the standard drug. Mean writhes of group B and C reduced significantly (P < 0.01) demonstrating analgesic effect.
CONCLUSION
CONCLUSIONS
The study validated the claim of Unani medicine of use of Habbe Gule Aakh in inflammation and pain. Further, phytochemical studies are needed to know the exact mechanism of action of this formulation.
Identifiants
pubmed: 30414716
pii: S0975-9476(17)30414-X
doi: 10.1016/j.jaim.2018.01.001
pmc: PMC8039358
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9-12Informations de copyright
Copyright © 2018 Transdisciplinary University, Bangalore and World Ayurveda Foundation. Published by Elsevier B.V. All rights reserved.
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