Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Adenosine Triphosphate
/ metabolism
Animals
Cell Line
Diabetes Mellitus, Type 2
/ metabolism
Glucagon
/ metabolism
Glucagon-Secreting Cells
/ cytology
Humans
Hyperglycemia
/ metabolism
Insulin
/ metabolism
Insulin-Secreting Cells
/ cytology
Male
Mice
Mice, Inbred C57BL
Potassium Channels
/ metabolism
Rats
Rats, Wistar
Sodium
/ metabolism
Fh1
diabetes
glucagon
sodium-glucose co-transport
succination
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
18
10
2017
revised:
23
07
2018
accepted:
13
10
2018
pubmed:
13
11
2018
medline:
9
4
2020
entrez:
13
11
2018
Statut:
ppublish
Résumé
Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tolbutamide and prevented by the sodium-glucose transport (SGLT) inhibitor phlorizin. These data link hyperglycemia, intracellular Na
Identifiants
pubmed: 30415925
pii: S1550-4131(18)30635-1
doi: 10.1016/j.cmet.2018.10.003
pmc: PMC6370947
pii:
doi:
Substances chimiques
Insulin
0
Potassium Channels
0
Adenosine Triphosphate
8L70Q75FXE
Glucagon
9007-92-5
Sodium
9NEZ333N27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
430-442.e4Subventions
Organisme : Medical Research Council
ID : MR/T002107/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 884655
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095531/Z/11/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801995
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 089795
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 095531
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Diabetologia. 2006 Feb;49(2):298-305
pubmed: 16365724
Diabetes. 2018 Jun;67(6):1128-1139
pubmed: 29563152
J Mol Cell Biol. 2012 Aug;4(4):221-30
pubmed: 22611253
Cell Rep. 2016 May 3;15(5):944-950
pubmed: 27117413
Diabetologia. 2014 Sep;57(9):1749-61
pubmed: 24906950
Diabet Med. 1998;15 Suppl 4:S8-12
pubmed: 9868985
Diabetes. 2008 Jan;57(1):41-9
pubmed: 17934141
Physiol Rev. 2013 Jan;93(1):137-88
pubmed: 23303908
Nat Rev Cardiol. 2017 Apr;14(4):238-250
pubmed: 28004807
Cell Rep. 2013 Mar 28;3(3):689-700
pubmed: 23499446
Eur J Med Chem. 2003 Jun;38(6):547-54
pubmed: 12832126
J Neurosci. 2011 Mar 9;31(10):3550-9
pubmed: 21389211
N Engl J Med. 2016 Nov 3;375(18):1801-2
pubmed: 27806236
Cell Metab. 2013 Dec 3;18(6):871-82
pubmed: 24315372
Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):179-83
pubmed: 14727006
Cancer Cell. 2007 Apr;11(4):311-9
pubmed: 17418408
Nat Med. 2015 May;21(5):512-7
pubmed: 25894829
Diabetes Obes Metab. 2011 Oct;13 Suppl 1:95-105
pubmed: 21824262
Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16009-12
pubmed: 20798346
Diabetes. 2013 Feb;62(2):653-61
pubmed: 23139355
Biochem J. 1953 Jan;53(1):67-71
pubmed: 13032035
Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1174-83
pubmed: 21862723
Development. 2000 Jun;127(11):2317-22
pubmed: 10804174
J Neurochem. 1986 Nov;47(5):1376-86
pubmed: 3760866
J Clin Invest. 2009 Jan;119(1):80-90
pubmed: 19065048
Diabetes. 2015 Sep;64(9):3172-81
pubmed: 25931473
Ann Med. 2003;35(8):632-9
pubmed: 14708972
Nat Commun. 2014 Aug 22;5:4639
pubmed: 25145789
N Engl J Med. 2015 Nov 26;373(22):2117-28
pubmed: 26378978
Pflugers Arch. 1986 Nov;407(5):493-9
pubmed: 2431383
Cell Metab. 2016 Aug 9;24(2):200-2
pubmed: 27508868
PLoS One. 2012;7(7):e39722
pubmed: 22829870
J Biol Chem. 1978 Dec 25;253(24):8702-7
pubmed: 31361
Nat Methods. 2009 Feb;6(2):161-6
pubmed: 19122669
Physiol Rev. 2011 Apr;91(2):733-94
pubmed: 21527736
Trends Endocrinol Metab. 2016 Jul;27(7):441-442
pubmed: 27215468
Diabetologia. 2002 Jul;45(7):937-48
pubmed: 12136392
Cell Rep. 2017 Sep 26;20(13):3135-3148
pubmed: 28954230
J Biol Chem. 2007 Nov 23;282(47):34219-28
pubmed: 17726021
Free Radic Res. 2011 Jan;45(1):101-9
pubmed: 20964553
Eur J Biochem. 1980 Aug;109(2):411-6
pubmed: 7408893
Cell Metab. 2017 Jul 5;26(1):27-38
pubmed: 28506519
Cell Rep. 2013 May 30;3(5):1440-8
pubmed: 23643539
Diabetologia. 2012 Sep;55(9):2445-55
pubmed: 22638549
FASEB J. 2010 Nov;24(11):4613-26
pubmed: 20647546
Diabetes. 2014 Jul;63(7):2188-95
pubmed: 24962915
Diabetologia. 2005 Sep;48(9):1700-13
pubmed: 16132964
Mol Metab. 2016 May 03;5(7):449-458
pubmed: 27408771
Genetics. 2006 Nov;174(3):1565-72
pubmed: 16951059
Nat Rev Mol Cell Biol. 2010 Jan;11(1):50-61
pubmed: 19997129
Cardiovasc Res. 2018 Jan 1;114(1):12-18
pubmed: 29016751
Nature. 2004 May 6;429(6987):41-6
pubmed: 15129273