Melatonin and its metabolites as chemical agents capable of directly repairing oxidized DNA.
DNA damage
electron transfer
hydrogen atom transfer
kinetics
melatonin
metabolites
reaction mechanism
Journal
Journal of pineal research
ISSN: 1600-079X
Titre abrégé: J Pineal Res
Pays: England
ID NLM: 8504412
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
18
09
2018
revised:
26
10
2018
accepted:
05
11
2018
pubmed:
13
11
2018
medline:
24
5
2019
entrez:
13
11
2018
Statut:
ppublish
Résumé
Oxidative stress mediates chemical damage to DNA yielding a wide variety of products. In this work, the potential capability of melatonin and several of its metabolites to repair directly (chemically) oxidative lesions in DNA was explored. It was found that all the investigated molecules are capable of repairing guanine-centered radical cations by electron transfer at very high rates, that is, diffusion-limited. They are also capable of repairing C-centered radicals in the sugar moiety of 2'-deoxyguanosine (2dG) by hydrogen atom transfer. Although this was identified as a rather slow process, with rate constants ranging from 1.75 to 5.32 × 10
Substances chimiques
4-hydroxymelatonin
0
DNA Adducts
0
Free Radical Scavengers
0
Melatonin
JL5DK93RCL
6-hydroxymelatonin
TV437T5077
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12539Subventions
Organisme : CONACyT, Fronteras de la Ciencia
ID : IFC-2016/1828
Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.