Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson's Disease.

Aged Female Humans Magnetic Resonance Imaging / methods Male Middle Aged Motor Cortex / diagnostic imaging Movement / physiology Nerve Net / diagnostic imaging Parkinson Disease / diagnostic imaging Principal Component Analysis / methods

Journal

Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718

Informations de publication

Date de publication:
01 01 2019
Historique:
received: 02 01 2018
pubmed: 13 11 2018
medline: 4 3 2020
entrez: 13 11 2018
Statut: ppublish

Résumé

Akinesia, a cardinal symptom of Parkinson's disease, has been linked to abnormal activation in putamen and posterior medial frontal cortex (pMFC). However, little is known whether clinical severity of akinesia is linked to dysfunctional connectivity of these regions. Using a seed-based approach, we here investigated resting-state functional connectivity (RSFC) of putamen, pMFC and primary motor cortex (M1) in 60 patients with Parkinson's disease on regular medication and 72 healthy controls. We found that in patients putamen featured decreases of connectivity for a number of cortical and subcortical areas engaged in sensorimotor and cognitive processing. In contrast, the pMFC showed reduced connectivity with a more focal cortical network involved in higher-level motor-cognition. Finally, M1 featured a selective disruption of connectivity in a network specifically connected with M1. Correlating clinical impairment with connectivity changes revealed a relationship between akinesia and reduced RSFC between pMFC and left intraparietal lobule (IPL). Together, the present study demonstrated RSFC decreases in networks for motor initiation and execution in Parkinson's disease. Moreover, results suggest a relationship between pMFC-IPL decoupling and the manifestation of akinetic symptoms.

Identifiants

DOI: 10.1093/cercor/bhy259 PMID: 30418548 PMC: PMC6294405
pubmed: 30418548
pii: 5174331
doi: 10.1093/cercor/bhy259
pmc: PMC6294405
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

383-396

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH074457
Pays : United States

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Auteurs

Lukas Hensel (L)

Department of Neurology, Cologne University Hospital, Cologne, Germany.
Institute of Neuroscience and Medicine, (INM-3: Cognitive Neuroscience), Research Centre Jülich, Jülich, Germany.

Felix Hoffstaedter (F)

Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Institute of Neuroscience and Medicine, (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany.

Julian Caspers (J)

Institute of Neuroscience and Medicine, (INM1: Structural and Functional Organization of the Brain), Research Centre Jülich, Jülich, Germany.
Department of Diagnostic and Interventional Radiology, University Düsseldorf, Medical Faculty, Düsseldorf, Germany.

Jochen Michely (J)

Department of Neurology, Cologne University Hospital, Cologne, Germany.
Wellcome Centre for Human Neuroimaging, University College London, London, UK.

Christian Mathys (C)

Department of Diagnostic and Interventional Radiology, University Du¨sseldorf, Medical Faculty, Düsseldorf, Germany.

Julia Heller (J)

Department of Neurology, RWTH Aachen University, Aachen, Germany.
JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Centre Jülich, Jülich, Germany.

Claudia R Eickhoff (CR)

Institute of Neuroscience and Medicine, (INM1: Structural and Functional Organization of the Brain), Research Centre Jülich, Jülich, Germany.
Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.

Kathrin Reetz (K)

Department of Neurology, RWTH Aachen University, Aachen, Germany.
JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Centre Jülich, Jülich, Germany.

Martin Südmeyer (M)

Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
Medical Faculty, Department of Neurology, Center for Movement Disorders and Neuromodulation, Heinrich Heine University, Düsseldorf, Germany.

Gereon R Fink (GR)

Department of Neurology, Cologne University Hospital, Cologne, Germany.
Institute of Neuroscience and Medicine, (INM-3: Cognitive Neuroscience), Research Centre Jülich, Jülich, Germany.

Alfons Schnitzler (A)

Medical Faculty, Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
Medical Faculty, Department of Neurology, Center for Movement Disorders and Neuromodulation, Heinrich Heine University, Düsseldorf, Germany.

Christian Grefkes (C)

Department of Neurology, Cologne University Hospital, Cologne, Germany.
Institute of Neuroscience and Medicine, (INM-3: Cognitive Neuroscience), Research Centre Jülich, Jülich, Germany.

Simon B Eickhoff (SB)

Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Institute of Neuroscience and Medicine, (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Cortex sensorimoteur › Cortex moteur › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Système nerveux › Réseau nerveux › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Functional Connectivity Changes of Key Regions...
questionsmedicales.fr › Techniques d'investigation › Analyse en composantes principales › Functional Connectivity Changes of Key Regions...