Contribution of NHE3 and dietary phosphate to lithium pharmacokinetics.
Bipolar
Excretion
Kidney
Lithium
Proximal tubule
Urine
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
01 Feb 2019
01 Feb 2019
Historique:
received:
27
07
2018
revised:
09
10
2018
accepted:
08
11
2018
pubmed:
13
11
2018
medline:
29
5
2019
entrez:
13
11
2018
Statut:
ppublish
Résumé
Lithium is one of the mainstays for the treatment of bipolar disorder despite its side effects on the endocrine, neurological, and renal systems. Experimentally, lithium has been used as a measure to determine proximal tubule reabsorption based on the assumption that lithium and sodium transport go in parallel in the proximal tubule. However, the exact mechanism by which lithium is reabsorbed remains elusive. The majority of proximal tubule sodium reabsorption is directly or indirectly mediated by the sodium-hydrogen exchanger 3 (NHE3). In addition, sodium-phosphate cotransporters have been implicated in renal lithium reabsorption. In order to better understand the role of sodium-phosphate cotransporters involved in lithium (re)absorption, we studied lithium pharmacokinetics in: i) tubule-specific NHE3 knockout mice (NHE3
Identifiants
pubmed: 30419292
pii: S0928-0987(18)30499-8
doi: 10.1016/j.ejps.2018.11.008
pmc: PMC6488027
mid: NIHMS1514280
pii:
doi:
Substances chimiques
Phosphates
0
Phosphorus, Dietary
0
Slc9a3 protein, mouse
0
Sodium-Hydrogen Exchanger 3
0
Lithium
9FN79X2M3F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK110621
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
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