Hemodynamic changes after acute fluid loading in patients with systemic sclerosis without pulmonary hypertension.
fluid challenge
pulmonary hypertension
systemic sclerosis
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Historique:
pubmed:
14
11
2018
medline:
14
11
2018
entrez:
14
11
2018
Statut:
ppublish
Résumé
A fluid challenge with a rapid infusion of saline helps to discriminate between pre- and post-capillary pulmonary hypertension (PH) and allows unmasking hidden post-capillary PH. Systemic sclerosis (SSc) patients may present with biventricular systolic and diastolic dysfunction. The aim of this study was to evaluate the hemodynamic changes of the pulmonary circulation in SSc patients without PH after a fluid challenge. Twenty-five SSc patients and 25 controls underwent right heart catheterization in basal conditions and after volume loading with saline infusion of 7 mL/kg over 5-10 min. At baseline, there was no difference in hemodynamics between SSc patients and controls. Rapid volume loading resulted in a significant increase in pressures and flows in both groups. Increases in right atrial pressure (3 ± 1 vs. 2 ± 1 mmHg, P = 0.03), mean pulmonary artery pressure (5 ± 1 vs. 3 ± 1 mmHg, P < 0.001), and pulmonary artery wedge pressure (PAWP; 5 ± 2 vs. 3 ± 1 mmHg, P < 0.001) were larger in SSc patients than in controls. Conversely, cardiac index (0.4 ± 0.2 vs. 0.6 ± 0.3 L/min/m
Identifiants
pubmed: 30419796
doi: 10.1177/2045894018816089
pmc: PMC6295705
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2045894018816089Références
Ann Rheum Dis. 2000 Feb;59(2):94-8
pubmed: 10666162
Ann Rheum Dis. 2001 Jun;60(6):592-8
pubmed: 11350848
Clin Exp Rheumatol. 2003;21(3 Suppl 29):S42-6
pubmed: 12889222
Clin Exp Rheumatol. 2003;21(3 Suppl 29):S47-8
pubmed: 12889223
Ann Rheum Dis. 2003 Sep;62(9):904-5
pubmed: 12922969
Eur J Echocardiogr. 2005 Dec;6(6):407-18
pubmed: 16293527
Ann Rheum Dis. 2008 Jan;67(1):31-6
pubmed: 17267515
Cardiology. 1991;79(3):165-71
pubmed: 1769033
Rheumatology (Oxford). 2011 Feb;50(2):317-23
pubmed: 20562195
Heart. 2011 Jan;97(2):112-7
pubmed: 20889989
Eur Heart J. 2011 Mar;32(6):670-9
pubmed: 21138935
Rheumatology (Oxford). 2012 Jun;51(6):1017-26
pubmed: 21900368
Arthritis Rheum. 1990 Nov;33(11):1620-5
pubmed: 2242060
Circulation. 2013 Jan 1;127(1):55-62
pubmed: 23172838
Eur Respir J. 2013 Oct;42(4):1083-91
pubmed: 23258775
Arthritis Rheum. 2013 Nov;65(11):2737-47
pubmed: 24122180
Semin Arthritis Rheum. 2014 Apr;43(5):673-80
pubmed: 24262931
Circ Heart Fail. 2014 Jan;7(1):2-4
pubmed: 24449809
J Rheumatol. 1989 Aug;16(8):1038-42
pubmed: 2585400
Eur Heart J. 2016 Jan 1;37(1):67-119
pubmed: 26320113
Chest. 2017 Jan;151(1):119-126
pubmed: 27575357
Int J Cardiol. 2018 Jun 15;261:167-171
pubmed: 29559180
Circulation. 2018 Aug 28;138(9):861-870
pubmed: 29792299
J Rheumatol. 1988 Feb;15(2):202-5
pubmed: 3361530
Circulation. 1994 Oct;90(4):2041-50
pubmed: 7923692
Ann Rheum Dis. 1996 Jul;55(7):455-60
pubmed: 8774164