Phospholipase C-β1 interacts with cyclin E in adipose- derived stem cells osteogenic differentiation.
Adipose derived stem cells
Cyclin E
Osteogenesis
PLC-β1
Stem cell differentiation
Journal
Advances in biological regulation
ISSN: 2212-4934
Titre abrégé: Adv Biol Regul
Pays: England
ID NLM: 101572336
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
22
10
2018
revised:
29
10
2018
accepted:
04
11
2018
pubmed:
14
11
2018
medline:
5
3
2020
entrez:
14
11
2018
Statut:
ppublish
Résumé
Adipose-derived stem cells (ADSCs) are multipotent mesenchymal stem cells that have the ability to differentiate into several cell types, including chondrocytes, osteoblasts, adipocytes, and neural cells. Given their easy accessibility and abundance, they became an attractive source of mesenchymal stem cells, as well as candidates for developing new treatments for reconstructive medicine and tissue engineering. Our study identifies a new signaling pathway that promotes ADSCs osteogenic differentiation and links the lipid signaling enzyme phospholipase C (PLC)-β1 to the expression of the cell cycle protein cyclin E. During osteogenic differentiation, PLC-β1 expression varies concomitantly with cyclin E expression and the two proteins interact. These findings contribute to clarify the pathways involved in osteogenic differentiation and provide evidence to develop therapeutic strategies for bone regeneration.
Identifiants
pubmed: 30420274
pii: S2212-4926(18)30152-0
doi: 10.1016/j.jbior.2018.11.001
pii:
doi:
Substances chimiques
CCNE1 protein, human
0
Cyclin E
0
Oncogene Proteins
0
PLCB1 protein, human
EC 3.1.4.11
Phospholipase C beta
EC 3.1.4.11
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-9Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.