A biomimetic receptor for glucose.
Journal
Nature chemistry
ISSN: 1755-4349
Titre abrégé: Nat Chem
Pays: England
ID NLM: 101499734
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
31
12
2017
accepted:
05
09
2018
pubmed:
14
11
2018
medline:
16
4
2019
entrez:
14
11
2018
Statut:
ppublish
Résumé
Specific molecular recognition is routine for biology, but has proved difficult to achieve in synthetic systems. Carbohydrate substrates are especially challenging, because of their diversity and similarity to water, the biological solvent. Here we report a synthetic receptor for glucose, which is biomimetic in both design and capabilities. The core structure is simple and symmetrical, yet provides a cavity which almost perfectly complements the all-equatorial β-pyranoside substrate. The receptor's affinity for glucose, at K
Identifiants
pubmed: 30420776
doi: 10.1038/s41557-018-0155-z
pii: 10.1038/s41557-018-0155-z
doi:
Substances chimiques
Lectins
0
Receptors, Artificial
0
Receptors, Cell Surface
0
glucose receptor
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM