The impact of timing of maternal influenza immunization on infant antibody levels at birth.
Adult
Antibodies, Viral
/ blood
Female
Humans
Immunity, Maternally-Acquired
/ immunology
Immunoglobulin G
/ blood
Infant
Infant, Newborn
Influenza A Virus, H1N1 Subtype
/ immunology
Influenza Vaccines
/ immunology
Influenza, Human
/ immunology
Maternal-Fetal Exchange
/ immunology
Pregnancy
Pregnancy Trimester, Second
/ immunology
Pregnancy Trimester, Third
/ immunology
Vaccination
human
vaccination
viral
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
accepted:
02
11
2018
pubmed:
14
11
2018
medline:
28
11
2019
entrez:
14
11
2018
Statut:
ppublish
Résumé
Pregnant women and infants are at an increased risk of severe disease after influenza infection. Maternal immunization is a potent tool to protect both these at-risk groups. While the primary aim of maternal influenza vaccination is to protect the mother, a secondary benefit is the transfer of protective antibodies to the infant. A recent study using the tetanus, diphtheria and acellular pertussis (Tdap) vaccine indicated that children born to mothers immunized in the second trimester of pregnancy had the highest antibody titres compared to children immunized in the third trimester. The aim of the current study was to investigate how the timing of maternal influenza immunization impacts infant antibody levels at birth. Antibody titres were assessed in maternal and cord blood samples by both immunoglobulin (Ig)G-binding enzyme-linked immunosorbent assay (ELISA) and haemagglutination inhibition assay (HAI). Antibody titres to the H1N1 component were significantly higher in infants born to mothers vaccinated in either the second or third trimesters than infants born to unvaccinated mothers. HAI levels in the infant were significantly lower when maternal immunization was performed less than 4 weeks before birth. These studies confirm that immunization during pregnancy increases the antibody titre in infants. Importantly, antibody levels in cord blood were significantly higher when the mother was vaccinated in either trimesters 2 or 3, although titres were significantly lower if the mother was immunized less than 4 weeks before birth. Based on these data, seasonal influenza vaccination should continue to be given in pregnancy as soon as it becomes available.
Identifiants
pubmed: 30422307
doi: 10.1111/cei.13234
pmc: PMC6330660
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Influenza Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
139-152Subventions
Organisme : Medical Research Council
ID : MC_UP_A900_1122
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00026/2
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2018 British Society for Immunology.
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