Preparation of an injectable modified chitosan-based hydrogel approaching for bone tissue engineering.
Bone
Chitosan
Cyclodextrin
Hydrogel
Injectable
Tissue engineering
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Feb 2019
15 Feb 2019
Historique:
received:
22
07
2018
revised:
13
10
2018
accepted:
08
11
2018
pubmed:
14
11
2018
medline:
11
4
2019
entrez:
14
11
2018
Statut:
ppublish
Résumé
This research aimed to design an injectable chitosan-based hydrogel for bone tissue engineering. To this end, chitosan should not only be soluble in water but also be thixotropic. Therefore, it can be used as an injectable liquid that can form a hydrogel under physiological conditions. Accordingly, chitosan was modified with carboxymethyl chloride and the resultant carboxymethyl chitosan (CMCTS) was conjugated to α-cyclodextrin (α-CD) to yield CMCTSCD. The α-CD conjugation improved the water solubility and the hydrophobic cavities to function as crosslinking points by forming an inclusion complex with poly(ethylene glycol) (PEG). The optimum mole ratio of α-CD (as CMCTSCD) to PEG was found to be 2 to 4 with a threading number of ~2.5. The sol-to-gel transition was formed within 450 ± 10 min. The interconnecting porous structure of the gel was observed by scanning electron microscope. Therefore, CMCTSCD/PEG is a potential novel design that can be used as an injectable hydrogel for bone tissue engineering.
Identifiants
pubmed: 30423397
pii: S0141-8130(18)33765-6
doi: 10.1016/j.ijbiomac.2018.11.041
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Hydrogels
0
alpha-Cyclodextrins
0
Polyethylene Glycols
3WJQ0SDW1A
Chitosan
9012-76-4
alpha-cyclodextrin
Z1LH97KTRM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-173Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.