Genetic variations in the ADCK1 gene predict paliperidone palmitate efficacy in Han Chinese patients with schizophrenia.
Adult
Antipsychotic Agents
/ administration & dosage
China
Female
Follow-Up Studies
Humans
Male
Paliperidone Palmitate
/ administration & dosage
Pharmacogenomic Testing
Pharmacogenomic Variants
Polymorphism, Single Nucleotide
Protein Kinases
/ genetics
Schizophrenia
/ drug therapy
Treatment Outcome
Young Adult
ADCK1
Paliperidone palmitate
Pharmacogenetics
Schizophrenia
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
28
05
2018
accepted:
04
11
2018
pubmed:
15
11
2018
medline:
13
6
2020
entrez:
15
11
2018
Statut:
ppublish
Résumé
Genome-wide association study results have linked ADCK1 genetic variation with paliperidone efficacy in a European cohort. However, the generalizability of this locus to non-European populations is unknown. Han Chinese schizophrenia patients (n = 159) were treated with paliperidone palmitate and symptom severity was assessed over 3 months. Examination of 13 ADCK1 genetic variants revealed two single nucleotide polymorphisms (rs12590199, rs11159291) and one haplotype (rs2364747-rs12590199) associated with paliperidone palmitate response. Future work into ADCK1's function and its potential interaction with paliperidone is warranted.
Identifiants
pubmed: 30426252
doi: 10.1007/s00702-018-1953-6
pii: 10.1007/s00702-018-1953-6
doi:
Substances chimiques
Antipsychotic Agents
0
ADCK1 protein, human
EC 2.7.-
Protein Kinases
EC 2.7.-
Paliperidone Palmitate
R8P8USM8FR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-25Subventions
Organisme : National Natural Science Foundation of China
ID : 81630031
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81571312
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81601184
Pays : International
Organisme : Capital Medical Development Research Fund
ID : 2016-1-4111
Pays : International
Organisme : Beijing Municipal Science and Technology Project
ID : Z171100000117016
Pays : International
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