Molecular aspects of Rift Valley fever virus and the emergence of reassortants.
Genetic diversity
Phlebovirus
Reassortment
Replication
Rift Valley fever
Journal
Virus genes
ISSN: 1572-994X
Titre abrégé: Virus Genes
Pays: United States
ID NLM: 8803967
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
22
02
2018
accepted:
03
11
2018
pubmed:
15
11
2018
medline:
23
2
2019
entrez:
15
11
2018
Statut:
ppublish
Résumé
Rift Valley fever phlebovirus (RVFV) is a mosquito-transmitted pathogen endemic to sub-Saharan Africa and the Arabian Peninsula. RVFV is a threat to both animal and human health and has costly economic consequences mainly related to livestock production and trade. Competent hosts and vectors for RVFV are widespread, existing outside of endemic countries including the USA. Thus, the possibility of RVFV spreading to the USA or other countries worldwide is of significant concern. RVFV (genus Phlebovirus) is comprised of an enveloped virion containing a three-segmented, negative-stranded RNA genome that is able to undergo genetic reassortment. Reassortment has the potential to produce viruses that are more pathogenic, easily transmissible, and that have wider vector or host range. This is especially concerning because of the wide use of live attenuated vaccine strains throughout endemic countries. This review focuses on the molecular aspects of RVFV, genetic diversity of RVFV strains, and RVFV reassortment.
Identifiants
pubmed: 30426314
doi: 10.1007/s11262-018-1611-y
pii: 10.1007/s11262-018-1611-y
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-11Références
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