Defining differences in patient characteristics between spasmodic dysphonia and laryngeal tremor.
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
05
04
2017
revised:
10
03
2018
accepted:
26
03
2018
pubmed:
15
11
2018
medline:
18
5
2019
entrez:
15
11
2018
Statut:
ppublish
Résumé
To compare presenting characteristics of patients with adductor spasmodic dysphonia (ADSD), ADSD with laryngeal tremor (ADSD + LT), and laryngeal tremor without ADSD (LT). Cross-sectional analysis. Patients treated for laryngeal movement disorders (1990-2016) were included. Analysis of variance and chi square tests measured differences in patient characteristics across the three disease groups. Using ADSD as the referent, multivariable logistic regression models were used to determine whether potential risk factors including patient demographics, family history, presence of potential inciting events prior to disease onset, and coprevalent movement disorders were associated with ADSD + LT or LT. In all, 652 patients with ADSD (n = 377), ADSD + LT (n = 98), and LT (n = 177) were included. ADSD patients were significantly younger than those with ADSD + LT and LT (52.5 ± 13.4, 63.9 ± 11.3, and 69.3 ± 10.5 years, respectively; P < 0.001). Coprevalent movement disorders were more common in ADSD + LT (38.7%) and LT (57.1%) groups than in the ADSD group (11.5%; P < 0.001). Compared to ADSD, patients with ADSD + LT and LT were more likely to develop an additional movement disorder during follow-up. In multivariable analyses, increasing age, female gender, and having a movement disorder at presentation were associated with significantly greater odds of having ADSD + LT or LT when compared to ADSD. ADSD + LT patients demonstrate intermediate gender composition and age distributions between those with ADSD and LT. These findings suggest that ADSD + LT may be a distinct phenotype in the spectrum of laryngeal movement disorders. 4 Laryngoscope, 129:170-176, 2019.
Identifiants
pubmed: 30426500
doi: 10.1002/lary.27245
pmc: PMC6320291
mid: NIHMS956024
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
170-176Subventions
Organisme : National Institute for Deafness and Communication Disorders (NIDCD) of the NIH
ID : K23DC013559
Pays : International
Organisme : National Institute for Deafness and Communication Disorders (NIDCD) of the NIH
ID : L30DC012687
Pays : International
Organisme : NCRR NIH HHS
ID : KL2 RR024977
Pays : United States
Organisme : NIDCD NIH HHS
ID : L30 DC012687
Pays : United States
Organisme : NIDCD NIH HHS
ID : K23 DC013559
Pays : United States
Informations de copyright
© 2018 The American Laryngological, Rhinological and Otological Society, Inc.
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