Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts.
AMP-Activated Protein Kinases
/ metabolism
Animals
Aquaporin 2
/ metabolism
Body Water
/ metabolism
Endocytosis
Female
Kidney Tubules, Collecting
/ drug effects
Male
Osmolar Concentration
Osmoregulation
Permeability
Phosphorylation
Protein Kinase C
/ metabolism
Rats
Renal Reabsorption
/ drug effects
Saline Solution, Hypertonic
/ pharmacology
AMPK
PKC
hypertonicity
nephrogenic diabetes insipidus
water transport
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
pubmed:
15
11
2018
medline:
26
11
2019
entrez:
15
11
2018
Statut:
ppublish
Résumé
Hypertonicity increases water permeability, independently of vasopressin, in the inner medullary collecting duct (IMCD) by increasing aquaporin-2 (AQP2) membrane accumulation. We investigated whether protein kinase C (PKC) and adenosine monophosphate kinase (AMPK) are involved in hypertonicity-regulated water permeability. Increasing perfusate osmolality from 150 to 290 mosmol/kgH
Identifiants
pubmed: 30427219
doi: 10.1152/ajprenal.00491.2017
pmc: PMC6397368
doi:
Substances chimiques
Aqp2 protein, rat
0
Aquaporin 2
0
Saline Solution, Hypertonic
0
Protein Kinase C
EC 2.7.11.13
AMP-Activated Protein Kinases
EC 2.7.11.31
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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