Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding.
2-oxoglutarate oxygenase
OGFOD1
barbiturate
epigenetics
histone demethylases
inhibitors
medicinal chemistry
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
06 Feb 2019
06 Feb 2019
Historique:
received:
19
09
2018
pubmed:
15
11
2018
medline:
1
8
2019
entrez:
15
11
2018
Statut:
ppublish
Résumé
Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.
Identifiants
pubmed: 30427558
doi: 10.1002/chem.201804790
pmc: PMC6471485
doi:
Substances chimiques
Carrier Proteins
0
Nuclear Proteins
0
OGFOD1 protein, human
0
Prolyl-Hydroxylase Inhibitors
0
Prolyl Hydroxylases
EC 1.14.11.-
Types de publication
Journal Article
Langues
eng
Pagination
2019-2024Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/D011523/1
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 20522
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106244/Z/14/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C5255/A16466
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L009846/1
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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