Effects of conflict and strategic processing on neural responses to errors in schizophrenia.
Conflict
EEG
ERN
ERP
Performance-monitoring
Schizophrenia
Journal
Biological psychology
ISSN: 1873-6246
Titre abrégé: Biol Psychol
Pays: Netherlands
ID NLM: 0375566
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
06
09
2017
revised:
13
10
2018
accepted:
05
11
2018
pubmed:
15
11
2018
medline:
2
5
2019
entrez:
15
11
2018
Statut:
ppublish
Résumé
The error-related negativity (ERN) and error-positivity (Pe) are commonly linked to error-detection and strategic processing. Studies have documented the influence of conflict probability on ERN amplitude. However, the influence of conflict probability on ERN/Pe in schizophrenia, where such components are reduced, is unknown. A modified flanker paradigm was used to examine how the probability of conflict modulates ERN and Pe amplitudes in patients with schizophrenia (n = 33) and healthy controls (n = 25). Increased ERN was observed in response to errors on low probability, incongruent trials. No such differences were observed in Pe. While ERN and Pe showed significantly reduced amplitudes in patients relative to controls, patients showed normal condition-dependent ERN and reaction-time modulation. This suggests that while the neural mechanisms generating the ERN and Pe are compromised in schizophrenia, those modulating task performance strategy and neurophysiological responses to errors based on conflict probability are intact.
Identifiants
pubmed: 30428312
pii: S0301-0511(18)30282-5
doi: 10.1016/j.biopsycho.2018.11.001
pii:
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-18Informations de copyright
Published by Elsevier B.V.