1,2,3-Triazole-based kojic acid analogs as potent tyrosinase inhibitors: Design, synthesis and biological evaluation.
Animals
Catalytic Domain
Cell Line, Tumor
Chelating Agents
/ chemical synthesis
Click Chemistry
Drug Design
Enzyme Inhibitors
/ chemical synthesis
Humans
Metals
/ chemistry
Mice
Molecular Docking Simulation
Molecular Structure
Monophenol Monooxygenase
/ antagonists & inhibitors
Pyrones
/ chemical synthesis
Structure-Activity Relationship
Triazoles
/ chemical synthesis
1,2,3-Triazole
Click reaction
Hyperpigmentation
Kojic acid
Tyrosinase inhibitor
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
10
08
2018
revised:
30
10
2018
accepted:
30
10
2018
pubmed:
15
11
2018
medline:
31
8
2019
entrez:
15
11
2018
Statut:
ppublish
Résumé
A series of kojic acid-derived compounds 6a-p bearing aryloxymethyl-1H-1,2,3-triazol-1-yl moiety were designed by modifying primary alcoholic group of kojic acid as tyrosinase inhibitors. The target compounds 6a-p were synthesized via click reaction. All compounds showed very potent anti-tyrosinase activity (IC
Identifiants
pubmed: 30428420
pii: S0045-2068(18)30861-7
doi: 10.1016/j.bioorg.2018.10.069
pii:
doi:
Substances chimiques
Chelating Agents
0
Enzyme Inhibitors
0
Metals
0
Pyrones
0
Triazoles
0
kojic acid
6K23F1TT52
Monophenol Monooxygenase
EC 1.14.18.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
414-422Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.