In Vivo PET Tracking of

Alendronate / therapeutic use Animals Breast Neoplasms / diagnostic imaging Cell Line, Tumor Diphosphonates / therapeutic use Female Humans Immunotherapy, Adoptive Mice Nanomedicine / methods Positron-Emission Tomography / methods T-Lymphocytes / cytology Xenograft Model Antitumor Assays
PET bisphosphonate cancer immunotherapy cell immunotherapy cell tracking liposome nanomedicine zirconium-89

Journal

Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581

Informations de publication

Date de publication:
02 01 2019
Historique:
received: 05 06 2018
revised: 03 10 2018
accepted: 08 10 2018
pubmed: 16 11 2018
medline: 18 12 2019
entrez: 16 11 2018
Statut: ppublish

Résumé

Gammadelta T (γδ-T) cells are strong candidates for adoptive immunotherapy in oncology due to their cytotoxicity, ease of expansion, and favorable safety profile. The development of γδ-T cell therapies would benefit from non-invasive cell-tracking methods and increased targeting to tumor sites. Here we report the use of [

Identifiants

DOI: 10.1016/j.ymthe.2018.10.006 PMID: 30429045 PMC: PMC6318719
pubmed: 30429045
pii: S1525-0016(18)30495-7
doi: 10.1016/j.ymthe.2018.10.006
pmc: PMC6318719
pii:
doi:

Substances chimiques

Diphosphonates 0
Alendronate X1J18R4W8P

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

219-229

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14105
Pays : United Kingdom

Informations de copyright

Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Francis Man (F)

School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK.

Lindsay Lim (L)

School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK.

Alessia Volpe (A)

School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK.

Alberto Gabizon (A)

Oncology Institute, Shaare Zedek Medical Center and Hebrew University-School of Medicine, Jerusalem 9103102, Israel.

Hilary Shmeeda (H)

Oncology Institute, Shaare Zedek Medical Center and Hebrew University-School of Medicine, Jerusalem 9103102, Israel.

Benjamin Draper (B)

School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital, London SE1 9RT, UK.

Ana C Parente-Pereira (AC)

School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital, London SE1 9RT, UK.

John Maher (J)

School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital, London SE1 9RT, UK.

Philip J Blower (PJ)

School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK.

Gilbert O Fruhwirth (GO)

School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK.

Rafael T M de Rosales (R)

School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, UK. Electronic address: rafael.torres@kcl.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Alendronate › In Vivo PET Tracking of
questionsmedicales.fr › Eucaryotes › Animaux › In Vivo PET Tracking of
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › In Vivo PET Tracking of
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › In Vivo PET Tracking of
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › In Vivo PET Tracking of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › In Vivo PET Tracking of
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Immunothérapie adoptive › In Vivo PET Tracking of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › In Vivo PET Tracking of
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Nanotechnologie › Nanomédecine › In Vivo PET Tracking of
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › In Vivo PET Tracking of
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › In Vivo PET Tracking of
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › In Vivo PET Tracking of