Atheroprotective effect of novel peptides from Porphyridium purpureum in RAW 264.7 macrophage cell line and its molecular docking study.
Animals
Atherosclerosis
/ metabolism
CD36 Antigens
/ metabolism
Interleukin-6
/ metabolism
Mice
Molecular Docking Simulation
Peptides
/ chemistry
Plant Proteins
/ chemistry
Porphyridium
/ chemistry
RAW 264.7 Cells
Tumor Necrosis Factor-alpha
/ metabolism
p38 Mitogen-Activated Protein Kinases
/ metabolism
Atherosclerosis
Docking
Low-density lipoprotein
Macrophages
Peptides
Phycoerythrin
Porphyridium purpureum
Journal
Biotechnology letters
ISSN: 1573-6776
Titre abrégé: Biotechnol Lett
Pays: Netherlands
ID NLM: 8008051
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
06
05
2018
accepted:
30
10
2018
pubmed:
16
11
2018
medline:
11
4
2019
entrez:
16
11
2018
Statut:
ppublish
Résumé
To explore the atherogenic foam cell prevention efficiency of two dipeptides purified from Porphyridium purpureum on RAW 264.7 cell line and to study its molecular interaction through molecular docking. P. purpureum consists of 29.9% protein and 2.98% phycoerythrin on a dry weight basis. The two dipeptides namely of Histidine-Glutamic acid (HE) and Glycine-Proline (GP) isolated from the total protein and purified phycoerythrin of P. purpureum respectively, were evaluated for atherogenic foam cell prevention capacity in RAW 264.7 cell line. The IC The cell line and molecular docking study indicated that among the two dipeptides, peptide GP has the highest atherogenic foam cell prevention efficiency.
Identifiants
pubmed: 30430406
doi: 10.1007/s10529-018-2621-5
pii: 10.1007/s10529-018-2621-5
doi:
Substances chimiques
CD36 Antigens
0
Interleukin-6
0
Peptides
0
Plant Proteins
0
Tumor Necrosis Factor-alpha
0
interleukin-6, mouse
0
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
91-106Subventions
Organisme : Indian Council of Medical Research
ID : 3/1/2/9/2011-RHN