Helicobacter pylori infection and prevalence of stroke.
Helicobacter pylori infection
cross-sectional study
peptic ulcer disease
stroke
Journal
Helicobacter
ISSN: 1523-5378
Titre abrégé: Helicobacter
Pays: England
ID NLM: 9605411
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
31
07
2018
revised:
05
10
2018
accepted:
08
10
2018
pubmed:
16
11
2018
medline:
25
4
2019
entrez:
16
11
2018
Statut:
ppublish
Résumé
Helicobacter pylori causes peptic ulcer disease; however, conflicting evidence exists regarding its role in extragastric conditions. We aimed to examine associations of H pylori infection and peptic ulcer disease with stroke. A cross-sectional study was undertaken using data of 147 936 individuals aged 25-95 years who underwent the urea breath test during 2002-2012, based on the computerized database of the second largest health maintenance organization in Israel. Logistic regression models were fitted to control for potential confounders. Overall, 1397 (0.9%) patients had stroke and 76 965 (52.0%) had a H pylori positive test. The likelihood of prevalent stroke increased in relation to H pylori infection: adjusted odds ratio (aOR) 1.16 (95% confidence intervals [CI]: 1.04-1.29), gastric ulcer: aOR 1.50 (95% CI: 1.18-1.91), and duodenal ulcer: aOR 1.25 (95% CI: 1.07-1.46). The results support the premise that stroke may be associated with a history of H pylori infection.
Sections du résumé
BACKGROUND
BACKGROUND
Helicobacter pylori causes peptic ulcer disease; however, conflicting evidence exists regarding its role in extragastric conditions. We aimed to examine associations of H pylori infection and peptic ulcer disease with stroke.
METHODS
METHODS
A cross-sectional study was undertaken using data of 147 936 individuals aged 25-95 years who underwent the urea breath test during 2002-2012, based on the computerized database of the second largest health maintenance organization in Israel. Logistic regression models were fitted to control for potential confounders.
RESULTS
RESULTS
Overall, 1397 (0.9%) patients had stroke and 76 965 (52.0%) had a H pylori positive test. The likelihood of prevalent stroke increased in relation to H pylori infection: adjusted odds ratio (aOR) 1.16 (95% confidence intervals [CI]: 1.04-1.29), gastric ulcer: aOR 1.50 (95% CI: 1.18-1.91), and duodenal ulcer: aOR 1.25 (95% CI: 1.07-1.46).
CONCLUSIONS
CONCLUSIONS
The results support the premise that stroke may be associated with a history of H pylori infection.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12553Subventions
Organisme : Council for Higher Education-Israel (KM-PI)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 John Wiley & Sons Ltd.