Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study.
Black or African American
Aged
Atherosclerosis
/ diagnostic imaging
Cognitive Dysfunction
/ diagnostic imaging
Dementia
/ diagnostic imaging
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Retinal Diseases
/ diagnostic imaging
Retinal Vessels
/ diagnostic imaging
Risk Factors
White People
Cohort studies
Dementia
Diabetes
Microvasculature
Retinal
Risk factors in epidemiology
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
22
03
2018
revised:
24
09
2018
accepted:
03
10
2018
pubmed:
16
11
2018
medline:
6
5
2020
entrez:
16
11
2018
Statut:
ppublish
Résumé
The easily-imaged retinal microvasculature may reflect the brain microvasculature and therefore be related to dementia. In a population-based study of 12,482 adults aged 50-73 years (22% African American), we estimated the relationship of retinal characteristics from fundus photography (1993-1995) with incident all-cause dementia (1993-1995 to 2011-2013) and with etiologic subtype of dementia/mild cognitive impairment (2011-13). A total of 1259 (10%) participants developed dementia over a mean 15.6 years. Moderate/severe (vs. no) retinopathy (hazard ratio [HR], 1.86; 95% confidence interval [CI]: 1.36-2.55) and central retinal arteriolar equivalent (narrowest quartile vs. widest three quartiles; HR, 1.26; 95% CI: 1.09-1.45) were associated with all-cause dementia. Results were qualitatively stronger (but not statistically significantly different) in participants with diabetes. Retinopathy was associated with a joint outcome of cerebrovascular-related, but not Alzheimer's disease-related, dementia/mild cognitive impairment (HR, 2.29; 95% CI: 1.24-4.23). Exploration of measures in the eye may provide surrogate indices of microvascular lesions relevant to dementia.
Identifiants
pubmed: 30439332
pii: S1552-5260(18)33562-3
doi: 10.1016/j.jalz.2018.10.002
pmc: PMC6408967
mid: NIHMS1509841
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
477-486Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG054693
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201000021C
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Informations de copyright
Copyright © 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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